Cardiolipin
Cardiolipin (IUPAC-navn: 1,3-bis(sn-3’-fosfatidyl)-sn-glycerol) er et fosfolipid, som udgør en vigtig bestanddel af mitokondriers indermembran, hvor det udgør 20 % af den samlede lipidmængde. Cardiolipin forekommer derudover kun i bakteriers cellemembraner. Navnet cardiolipin skyldes, at lipidet blev opdaget i hjerter fra tamkvæg i 1941.[1] I pattedyr- og planteceller[2][3] forekommer cardiolipin (CL) stort set udelukkende i mitokondriernes indermembran. Cardiolipin er et "dobbelt" fosfolipid og indeholder derfor to fosfatgrupper samt fire fedtsyrer, og denne kompakte struktur er med til at gøre mitokondriets indermembran uigennemtrængelig.[4]
Noter
- ^ Pangborn, Mary. 'Isolation and purification of a serologically active phospholipid from beef heart'. I The Journal of Biological Chemistry, volume 143 (1942), s. 247–256. (engelsk)
- ^ Nowicki, Marcin, Frank Müller, og Margrit Frentzen. 'Cardiolipin synthase of Arabidopsis thaliana'. I FEBS Letters, volume 579, issue 10 (2005), s. 2161–2165. DOI:10.1016/j.febslet.2005.03.007. PMID 15811335. (engelsk)
- ^ Nowicki, Marcin. 'Characterization of the Cardiolipin Synthase from Arabidopsis thaliana' Arkiveret 5. oktober 2011 hos Wayback Machine. Ph.d.-afhandling, RWTH-Aachen University. (tysk) (engelsk)
- ^ Alberts, Bruce, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, og Peter Walter. Molecular Biology of the Cell. New York: Garland Publishing Inc., 1994, ISBN 0-8153-3218-1. (engelsk)
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