Digoxin
Digoxin (også kendt som digitalis) er et lægemiddel, der bruges til behandling af hjertesygdomme. Digoxin bruges især til behandling af atrieflimren.[1]
 | |
| Farmakokinetiske data | |
|---|---|
| Halveringstid | 36 timer (mere ved nyresvigt) |
| Udskillelse | Nyre |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.040.047 |
Digoxin primære funktionelle mekanisme er at hæmme natrium-kalium-pumpen, hvilket øger det intracellulære niveau af Na⁺, der fører til reduceret aktivitet af natrium-calcium-veksleren. Dette øger det intracellulære niveau af Ca²⁺, hvilket har en positiv inotropisk effekt.[2] Desuden reducerer digoxin hjertets puls gennem stimulering af vagal (parasympatisk) tone.[3][4][1]
Digoxin kan være giftig og livstruende i for høje mængder.[3]
Referencer
- ^ a b Ferrari, Filipe; Santander, Igor R.M.F.; Stein, Ricardo (maj 2022). "Digoxin in Atrial Fibrillation: An Old Topic Revisited". Current Cardiology Reviews. 16 (2): 141-146. doi:10.2174/1573403X15666190618110941. ISSN 1573-403X. PMC 7460705. PMID 31237216.
- ^ Smith, T. W. (1988-02-11). "Digitalis. Mechanisms of action and clinical use". The New England Journal of Medicine. 318 (6): 358-365. doi:10.1056/NEJM198802113180606. ISSN 0028-4793. PMID 3277052.
- ^ a b "Digitalisforgiftning". Lægehåndbogen. Hentet 13. september 2022.
{{cite web}}: CS1-vedligeholdelse: url-status (link) - ^ Watanabe, A. M. (1985-05-05). "Digitalis and the autonomic nervous system". Journal of the American College of Cardiology. 5 (5 Suppl A): 35A-42A. doi:10.1016/s0735-1097(85)80461-7. ISSN 0735-1097. PMID 3886751.
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