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Frameshift-mutation

På dette billede ses en frameshift-mutation (af mRNA) hvor nukleotidet uracil (U) bliver slettet fra sekvensen, resulterende i en ændring af to udtrykte aminosyrer og et tidligt stop af proteinet.

En frameshift-mutation er en genetisk mutation, forårsaget af en insertion eller deletion af et antal nukleotider, der ikke er delelig med tre. Som DNA læses i tripletter (se codon) kan en ændring i grupperingen af disse codoner resultere i en fuldstændig anderledes translation af sekvensen.

Se også

Mutation

Nonsensmutation

Missense-mutation

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