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Haloperidol

Haloperidol
Kliniske data
HandelsnavneSerenase, Haldol
Administrationsvejp.o., i.v., i.m.
ATC-kode
Fysiologiske data
MetabolismeLever
Juridisk status
Juridisk status
  • DK: B
Farmakokinetiske data
Biotilgængelighed50-60% (peroral)
MetabolismeLever
Halveringstid10-30 timer
UdskillelseGalde og urin
Identifikatorer
  • 4-[4-(4-chlorphenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorphenyl)-butan-1-on
CAS-nummer
PubChem CID
DrugBank
CompTox Dashboard (EPA)
ECHA InfoCard100.000.142 Redigér dette på Wikidata
Kemiske og fysiske data
FormelC21H23ClFNO2
Molarmasse375,9 g·mol−1
3D-model (JSmol)
  • c1cc(ccc1C(=O)CCCN2CCC(CC2)(c3ccc(cc3)Cl)O)F
  • InChI=InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
  • Key:LNEPOXFFQSENCJ-UHFFFAOYSA-N

Haloperidol (med handelsnavnene Haldol og Serenase®) er et ældre antipsykotikum. Stoffet er en dopamin invers agonist.

Haloperidol anvendes til behandling af skizofreni og andre psykotiske tilstande. Desuden kan det anvendes mod kemoterapi- eller stråleinduceret kvalme og opkastning.

Haloperidol findes også som langtidsvirkende depotformulering i form af dekanoat ester. Denne formulering gives som intramuskulær injektion hver 3.-4. uge.

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