The 1991–92 season saw Sampdoria compete in this season's editions of the Serie A, Coppa Italia, and European Cup. The club reached the 1992 European Cup Final only to suffer a 1–0 loss in extra time to Barcelona.
In the league, Sampdoria finished tied for sixth with Parma. Due to Sampdoria's failure to secure European football, championship-winning coach Vujadin Boškov left his job.
Squad
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
^The match was played in Sofia, Bulgaria since UEFA suspended Yugoslav teams from playing their home matches in Yugoslavia due to the deteriorating security situation in the country caused by the ethnic incidents that eventually turned into the Yugoslav Wars.