† Three clubs, as the three highest placed finishers of the 2009 CFU Club Championship among the qualified clubs, were awarded a bye into the second round. W Connection, the 2009 CFU champions, did not qualify for the 2010 tournament.
‡ Elite SC and Bath Estate withdrew before playing any matches.[2][3]
The competition was initially announced by the CFU to be structures similarly to the previous year, during which several team played two-legged playoffs and other seed teams received byes in the later knockout rounds.[1] However, the format was changed at the 2010 CFU Congress, where it was decided that three rounds of group stages would be used.[4] Also, Haiti, who had not initially entered any clubs into the tournament, added Racing Gonaïves and Tempête. Elite SC from Cayman Islands were also later added.[5] However, Elite SC and Bath Estate later withdrew from the tournament, and Guyana Defence Force were moved to Group D due to travel and immigration difficulties.[2][3] Those changes reduced Group B to two teams, both of which qualify to the second round.[2]
First round
The top two teams from each group as well as the highest ranked third place team advance to the second round.
In the second round, only the group winners advance to the final round.
After the completion of the first round, the following changes to the second round have been made:
Alpha United traded places with Leo Victor, allowing the matches to be staged as schedule by avoiding travel delays due to U.S. restrictions for the Guyanese club.[6]
The matches in Group E and Group F were postponed due to delays by Haitian clubs Tempete FC and Racing Gonaives in obtaining U.S. visas to travel to Puerto Rico.[7]
The matches in Group G and Group H were postponed due to stadium availability and were scheduled to begin a day later than previously announced.[8]
Leo Victor withdrew from Group E for financial reasons, and Tempête was forced to withdraw from Group F following difficulties in obtaining visas to Puerto Rico.[9] Therefore both Group E and F would be played as two-team groups.