The 2021–22 season was the 69th season in the existence of CD Lugo and the club's 10th consecutive season in the second division of Spanish football. In addition to the domestic league, Lugo participated in this season's edition of the Copa del Rey.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.