Matteo Berrettini defeated Cameron Norrie in the final, 6–4, 6–7(5–7), 6–3, to win the singles tennis title at the 2021 Queen's Club Championships. Berrettini's win earned him his fourth career ATP Tour singles title, his first ATP 500 victory, and also made him the first player to win the tournament on their main draw debut since Boris Becker in 1985. Norrie was contesting for his first title in his fourth career final.[1]