Fermín Aldeguer signed a Ducati factory contract in March 2024, and was confirmed to be racing for Gresini Racing on 28 August 2024 replacing the factory Ducati bound Marc Márquez.[28]
Marc Márquez and Jorge Martín were linked with the Lenovo Ducati factory squad all throughout the first half of the season as the top performing Ducatis. In Barcelona and Mugello, it was set to be confirmed that Jorge Martin would replace Bastianini, but after the Italian Grand Prix weekend, it was reported that Marquez was chosen to replace Bastianini. During the Mugello Test, Jorge Martín announced that he would be joining Aprilia Racing, replacing the retiring Aleix Espargaró.[2] 2 days later, Ducati announced that Marc Márquez would join their factory team alongside Francesco Bagnaia.[6]
Aprilia Racing announced that Marco Bezzecchi would join alongside Jorge Martín, replacing Maverick Viñales.[1]
Pertamina Enduro VR46 Team announced that Franco Morbidelli would join alongside Fabio Di Giannantonio, riding a Desmosedici GP24, taking the seat of the factory Aprilia bound Marco Bezzecchi.[31]
Trackhouse Racing announced that reigning Moto2 World Champion Ai Ogura signed a two-year contract to ride alongside Raúl Fernández, replacing the satellite Yamaha bound Miguel Oliveira.[32]
LCR Honda announced that Somkiat Chantra would join alongside Johann Zarco, replacing the retiring Takaaki Nakagami, who left the team after seven seasons and will become test rider alongside Aleix Espargaró.[33]