Darrisaw rejoined Virginia Tech in 2018 and started at left tackle for the Hokies.[2][3][4] He would later start every game during the 2019 and 2020 seasons, being named to the first-team All-Atlantic Coast Conference team in the latter.[5]
Following the 2020 season he declared for the 2021 NFL draft, in which he was selected by the Minnesota Vikings in the first round, 23rd overall.[7] On May 14, 2021, Darrisaw signed his four-year rookie contract with the Vikings.[8] Darrisaw missed the first four games of his rookie season with a groin injury.[9] As a rookie, he appeared in 12 games and started ten.[10] In the 2022 season, he appeared in and started 14 games.[11] In the 2023 season, he appeared in and started 15 games.[12]
On April 29, 2024, the Vikings picked up the fifth-year option on Darrisaw's contract.[13] On July 23, 2024, the Vikings and Darrisaw agreed to a four-year contract extension worth up to $113 million.[14]
In Week 8 of the 2024 NFL season, Darrisaw suffered a knee injury in a game between the Vikings and the Los Angeles Rams. He was ruled out for the remainder of the season the next day.[15]