The club was founded on 2006 as Pixy BC. Former player Ichizo Nakata contributed in the club relocation to the Ise City, making it their new hometown at the Mie Prefecture.
It led the club to be renamed as FC Ise-Shima on 2013, when the club was playing on Mie's 2nd division. The club saw three back-to-back promotions from prefectural to regional level, debuting at the first division of the Tōkai Adult Soccer League on 2016. The club has not been relegated or had even been outside of the Top 4 ever since. They had the opportunity to be promoted to the Japan Football League a couple of times through the Japanese Regional Football Champions League, even finishing at fourth place at the 2021 edition of the competition. However, it was not enough to give them promotion.
Pos. = Position in league; P = Games played; W = Games won; D = Games drawn; L = Games lost; F = Goals scored; A = Goals conceded; GD = Goal difference; Pts = Points won
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
^"選手・スタッフ | FC.ISE-SHIMA" [Players, Staff | FC.ISE-SHIMA]. fc-iseshima.org (in Japanese). FC.ISE-SHIMA. Archived from the original on 2022-02-13. Retrieved 12 February 2022.
