Florida State Road 53

State Road 53
State Road 53
	SR 53 highlighted in red and CR 53 in blue
Route information
	Maintained by FDOT
Length	19.170 mi (30.851 km)
Major junctions
South end	I-10 / CR 53 near Madison
	US 90 in Madison
North end	SR 333 towards Quitman, GA
Location
Country	United States
State	Florida
Counties	Madison
Highway system
	Florida State Highway System; Interstate; US; State Former; Pre‑1945; ; Toll; Scenic;

State Road 53 (SR 53) is a 19.170-mile-long (30.851 km) north–south state highway in the panhandle of northern Florida. Its southern terminus is an interchange with Interstate 10 (I-10; which also carries the unsigned designation of SR 8) near Lee and Madison; the northern terminus is at the Georgia state line near Cherry Lake, Florida. Part of SR 53, from Harvey Greene Drive north to SR 14, is also signed SR 14 Truck, a rare special state highway in Florida.

SR 53 continues northward from the state line as State Route 333 (SR 333). A southbound continuation of SR 53 is County Road 53, which ultimately ends at an intersection with U.S. Route 27 (US 27; which also carries the unsigned designation of SR 20) in Buckville (northwest of Mayo). This is also the western terminus of CR 534.

Major intersections

County	Location	mi^[1]^[2]	km	Destinations	Notes
Lafayette	Buckville	0.000	0.000	US 27 (SR 20) / CR 534 – Mayo, Perry
		2.0^[3]	3.2	CR 290	former SR 348A east
		2.3^[3]	3.7	CR 348 west
	Day	4.5^[3]	7.2	CR 270 (Northwest Maine Avenue)	former SR 348B east
		5.8^[3]	9.3	CR 260	former SR 348C east
		8.1^[3]	13.0	CR 250 east – Advent Christian Village
Madison		9.4^[3]	15.1	CR 255 north
		19.515	31.406	south end of state maintenance
		19.84	31.93	I-10 (SR 8) – Tallahassee, Lake City	I-10 exit 258
		24.817	39.939	SR 14 Truck west (Harvey Greene Drive)	south end of SR 14 Truck overlap
	Madison	25.531	41.088	SR 14 west (Southwest Millinor Street)	north end of SR 14 Truck overlap
		26.014	41.865	US 90 east (Base Street / SR 10) / SR 145 north (Duval Street) – Live Oak, North Florida Community College	south end of US 90 / SR 10 overlap
		26.306	42.335	US 90 west (Base Street / SR 10) – Tallahassee, Greenville	north end of US 90 / SR 10 overlap
		28.091	45.208	CR 146 west (Northwest Little Cat Road)
	Cherry Lake	34.3^[3]	55.2	CR 150
		36.186	58.236	CR 253 east (Northeast Cherry Lake Circle) – Camp Cherry Lake 4-H Center
		36.266	58.364	CR 253 west
		38.685	62.257	SR 333 north (Madison Highway) – Quitman	Georgia state line
1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus Route transition