Hemoglobinuria

This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Find sources: "Hemoglobinuria" – news · newspapers · books · scholar · JSTOR (September 2017)

Hemoglobinuria
Other names	Haemoglobinuria
Structure of hemoglobin
Specialty	Urology, nephrology
Symptoms	Disease, Hemolytic anemia, Proteinuria
Causes	Acute glomerulonephritis; Burns; Renal cancer; Malaria; Paroxysmal nocturnal hemoglobinuria; Microangiopathies, e.g. hemolytic-uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP) leading to microangiopathic hemolytic anemia; Transfusion reactions; IgM autoimmune hemolytic anemia; Glucose-6-phosphate dehydrogenase deficiency; Pyelonephritis; Sickle cell anemia; Tuberculosis of the urinary tract; March hemoglobinuria secondary to repetitive impacts on the body, usually the feet; Athletic nephritis secondary to strenuous exercise; Acute lead poisoning

Hemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine.^[1] The condition is caused by excessive intravascular hemolysis, in which large numbers of red blood cells (RBCs) are destroyed, thereby releasing free hemoglobin into the plasma.^[2] Excess hemoglobin is filtered by the kidneys, which excrete it into the urine, giving urine a purple color. Hemoglobinuria can lead to acute tubular necrosis which is an uncommon cause of a death of uni-traumatic patients recovering in the ICU.

The diagnosis is often made based on the medical history, blood samples, and a urine sample. The absence of urine RBCs and RBC casts microscopically despite a positive dipstick test suggests hemoglobinuria or myoglobinuria. The medical term for RBCs in the urine is hematuria.

• Hematuria