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INHBA

INHBA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesINHBA, EDF, FRP, inhibin beta A, inhibin beta A subunit, inhibin subunit beta A
External IDsOMIM: 147290; MGI: 96570; HomoloGene: 1653; GeneCards: INHBA; OMA:INHBA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002192

NM_008380

RefSeq (protein)

NP_002183
NP_002183.1

NP_032406

Location (UCSC)Chr 7: 41.67 – 41.71 MbChr 13: 16.19 – 16.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inhibin, beta A, also known as INHBA, is a protein which in humans is encoded by the INHBA gene.[5] INHBA is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects.

Function

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary several fold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.[6]

Interactions

INHBA has been shown to interact with ACVR2A.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122641Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041324Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.
  6. ^ "Entrez Gene: INHBA inhibin, beta A (activin A, activin AB alpha polypeptide)".
  7. ^ Lewis KA, Gray P C, Blount A L, MacConell L A, Wiater E, Bilezikjian L M, Vale W (March 2000). "Betaglycan binds inhibin and can mediate functional antagonism of activin signalling". Nature. 404 (6776). ENGLAND: 411–4. Bibcode:2000Natur.404..411L. doi:10.1038/35006129. ISSN 0028-0836. PMID 10746731. S2CID 4393629.
  8. ^ Martens JW, de Winter J P, Timmerman M A, McLuskey A, van Schaik R H, Themmen A P, de Jong F H (July 1997). "Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells" (PDF). Endocrinology. 138 (7). UNITED STATES: 2928–36. doi:10.1210/endo.138.7.5250. ISSN 0013-7227. PMID 9202237.

Further reading

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