While working as a biomedical researcher at NTU, Chan started a blog called Asian Scientist.[4] She cited the need to escape from the "insularity and isolation" of scientific research in starting the blog. The blog became popular enough to lead to a partnership with the publishing house World Scientific Publishing, enabling Chan to turn Asian Scientist into a magazine and serve as its editor-in-chief.[5]
Chan founded Wildtype Media Group in 2018, leaving both her role as editor of Asian Scientist and running her research lab at NTU; Chan recognized the risk of taking on an entrepreneurial career but said she found a calling in helping to "make Asian scientists household names".[6] Wildtype is described as the first "STEM-focused media company in Singapore that provides professional science communication services to government agencies, industry, and academia in Singapore as well as the broader Asian region".[4]
Chan transitioned Wildtype to full remote work in August 2023, citing the impacts from the COVID-19 pandemic and calling remote work "the future of work".[8] She has also more recently transitioned into a being a LinkedIn coach, in order to help "executives build their professional brand".[6]