Alou was the middle of a trio of baseball-playing brothers that included the older Felipe and younger Jesús.[4] They were the first set of three siblings to all bat in the same half-inning in the majors (September 10),[5] and play together in the same outfield (on September 15),[6] accomplishing both with the Giants in 1963. The latter achievement happened in the last two innings of a 13–5 win over the Pittsburgh Pirates at Forbes Field, with starting right fielder Felipe first moving to left in the seventh inning when Jesús entered the game in right and then to center in the eighth when Matty was inserted in left.[7] Matty had been teammates with Felipe during the prior three campaigns, and was likewise with Jesús for the following two. Matty and Felipe later reunited with the Yankees in 1973.[8]
Alou was born in Haina, Dominican Republic. He was a platoon player for the Giants for several years and was mostly unremarkable. His finest moment in San Francisco came in 1962 when his pinch-hit bunt single in the final game of a three-game tie-breaking playoff against the Los Angeles Dodgers began the rally that won the game and the pennant for the Giants. He batted .333 in the Giants' losing effort against the Yankees in the 1962 World Series. While he was primarily an outfielder, Alou also appeared in one game in 1965 as a pitcher, pitching two scoreless innings.[9]
After being traded to the Pittsburgh Pirates before the 1966 season Alou received instruction from expert hitting instructor Harry "the Hat" Walker that helped turn him into a high-average contact hitter. This earned him a starting job as an integral member of a Pirates team which included future Baseball Hall of Fame members Roberto Clemente, Bill Mazeroski and Willie Stargell. The Pirates fought the Los Angeles Dodgers and San Francisco Giants in a tight pennant race and were in first place on September 10, before they faltered to finish the season in third place for a second consecutive year.[10] Alou won the 1966 NL batting title with a .342 average, with his brother Felipe finishing second, and finished in the top five in hitting four more times - in 1967–1969, 1971.
In 1969 Alou led the major leagues in at-bats (698), doubles (41), and hits (231). His 231 hits in 1969 remain the highest total by any National League player since Joe Medwick's 237 in 1937.[citation needed]
Alou died in Santo Domingo, Dominican Republic as the result of diabetic complications, according to his former Dominican team, Leones del Escogido. The Giants confirmed Alou had had variety of health issues for several years.[12]
Alou was honored in New York City by the naming of Matty Alou Way in Upper Manhattan's
Inwood Hill Park neighborhood in October 2015.[13]