The National African Federated Chamber of Commerce is a South African member body formed in 1964, which focused on the upliftment of black business people during Apartheid. It claims a membership of several hundred thousand and controls substantial investment funds.

It was formed in Johannesburg in 1964 to promote black entrepreneurship and businesses.^[1]: 77 Its origins are from a 1955 organisation, the African Chamber of Commerce.^[1]: 77 It was restructured a national organisation in 1969 with regional branches.^[1]: 77 Its founding president was the highly venerated late businessman, Richard Maponya.^[1]: 77 Prominent businessman, Patrice Motsepe is a former president, with the presidency currently (2020) occupied by prominent businessman Sabelo Macingwane who is also a former CEO of the organisation.

The organisation had the following aims:^[1]: 77

1. scrapping of discriminate measures against black business people;
2. development of black capital;
3. help establish a black middle-class.

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