Nucleoporin 85

NUP85
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A9Q
Identifiers
Aliases	NUP85, Nup75, FROUNT, nucleoporin 85, NPHS17
External IDs	OMIM: 170285; MGI: 3046173; HomoloGene: 11755; GeneCards: NUP85; OMA:NUP85 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,235,758 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,474,811 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; right testis; ; gonad; ; tibial nerve; ; left testis; ; mucosa of transverse colon; ; right ovary; ; right uterine tube; ; oocyte;
	Top expressed in
	fossa; ; condyle; ; primitive streak; ; zygote; ; primary oocyte; ; ventricular zone; ; epiblast; ; Paneth cell; ; secondary oocyte; ; Rostral migratory stream;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of nuclear pore; protein binding;
Cellular component	cytoplasm; nuclear membrane; membrane; nuclear envelope; spindle; nuclear pore; chromosome; nuclear pore outer ring; chromosome, centromeric region; cytoskeleton; kinetochore; nucleus; cytosol; host cell;
Biological process	mRNA transport; protein import into nucleus; viral transcription; protein sumoylation; positive regulation of transcription, DNA-templated; chemotaxis; mitotic nuclear membrane disassembly; macrophage chemotaxis; regulation of cellular response to heat; protein transport; viral process; lamellipodium assembly; intracellular transport of virus; mRNA export from nucleus; tRNA export from nucleus; sister chromatid cohesion; regulation of gene silencing by miRNA; regulation of glycolytic process; transport; nephron development; nucleocytoplasmic transport;
	Sources:Amigo / QuickGO
Orthologs
	79902
	445007
	ENSG00000125450
	ENSMUSG00000020739
	Q9BW27
	Q8R480
	NM_001303276; NM_024844; NM_001330472
	NM_001002929
	NP_001290205; NP_001317401; NP_079120
	NP_001002929
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene.^[5]^[6]

Function

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125450 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020739 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M (Feb 1994). "Pericentrin, a highly conserved centrosome protein involved in microtubule organization". Cell. 76 (4): 639–50. doi:10.1016/0092-8674(94)90504-5. PMID 8124707. S2CID 20503793.
^ ^a ^b "Entrez Gene: NUP85 nucleoporin 85kDa".

Kapeller R, Toker A, Cantley LC, Carpenter CL (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789.
Tynan SH, Purohit A, Doxsey SJ, Vallee RB (Oct 2000). "Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin". The Journal of Biological Chemistry. 275 (42): 32763–8. doi:10.1074/jbc.M001536200. PMID 10893222.
Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ (Sep 2002). "Proteomic analysis of the mammalian nuclear pore complex". The Journal of Cell Biology. 158 (5): 915–27. doi:10.1083/jcb.200206106. PMC 2173148. PMID 12196509.
Mulari MT, Patrikainen L, Kaisto T, Metsikkö K, Salo JJ, Väänänen HK (May 2003). "The architecture of microtubular network and Golgi orientation in osteoclasts--major differences between avian and mammalian species". Experimental Cell Research. 285 (2): 221–35. doi:10.1016/S0014-4827(03)00033-8. PMID 12706117.
Chang F, Re F, Sebastian S, Sazer S, Luban J (Apr 2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes". Molecular Biology of the Cell. 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMC 379276. PMID 14767062.
Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
Terashima Y, Onai N, Murai M, Enomoto M, Poonpiriya V, Hamada T, Motomura K, Suwa M, Ezaki T, Haga T, Kanegasaki S, Matsushima K (Aug 2005). "Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis". Nature Immunology. 6 (8): 827–35. doi:10.1038/ni1222. PMID 15995708. S2CID 23496938.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Satoh M, Akatsu T, Ishkawa Y, Minami Y, Nakamura M (Mar 2007). "A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart". Journal of Cardiac Failure. 13 (2): 114–9. doi:10.1016/j.cardfail.2006.11.003. PMID 17395051.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125450 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020739 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8124707-5] Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M (Feb 1994). "Pericentrin, a highly conserved centrosome protein involved in microtubule organization". Cell. 76 (4): 639–50. doi:10.1016/0092-8674(94)90504-5. PMID 8124707. S2CID 20503793.

[entrez-6] "Entrez Gene: NUP85 nucleoporin 85kDa".

[1]

[2]

[3]

[4]

[5]

[6]

Nucleoporin 85

Function

References

Further reading