Princess Caroline Louise
Hereditary Grand Duchess of Mecklenburg-Schwerin
Born	(1786-07-18)18 July 1786 Stadtschloss, Weimar
Died	20 January 1816(1816-01-20) (aged 29) Schloss Ludwigslust, Mecklenburg
Spouse	Frederick Louis, Hereditary Grand Duke of Mecklenburg-Schwerin ​ ​ (m. 1810)​
Issue	Duke Albert Hélène, Duchess of Orléans Duke Magnus
Names Karoline Luise
House	Saxe-Weimar-Eisenach
Father	Charles Augustus, Grand Duke of Saxe-Weimar-Eisenach
Mother	Louise of Hesse-Darmstadt

Princess Caroline Louise of Saxe-Weimar-Eisenach (Karoline Luise; 18 July 1786 – 20 January 1816) was a princess of Mecklenburg-Schwerin by virtue of her marriage. She was the daughter of Charles Augustus, Grand Duke of Saxe-Weimar-Eisenach and Louisa of Hesse-Darmstadt.

Caroline was born at the Stadtschloss in Weimar on 18 July 1786 as the princess of Saxe-Weimar-Eisenach by birth. The second of three children to reach adulthood, her older brother Charles Frederick succeeded their father as Grand Duke in 1828. One of Caroline's nieces was Empress Augusta of Germany, wife of William I, German Emperor.

On 1 July 1810, she became the second wife of Frederick Ludwig, Hereditary Grand Duke of Mecklenburg-Schwerin. The Hereditary Grand Duke had lost his first wife Elena Pavlovna of Russia in September 1804 having died of influenza. Caroline Louise gave her husband three children. Her only daughter married son of Louis Philippe I of the French. She had a loving relationship with her husband.^{[citation needed]}

After the birth of her youngest child, Prince Magnus, her health never recovered and she died aged 29 at the Schloss Ludwigslust. In her deathbed, she suggested her husband remarry to her cousin Auguste Fredericka, daughter of Frederick V of Hesse-Homburg; they married in April 1818.

1. Albert of Mecklenburg-Schwerin (11 February 1812 – 18 October 1834) died unmarried.
2. Hélène of Mecklenburg-Schwerin (24 January 1814 – 17 May 1858) married Ferdinand Philippe, Duke of Orléans and had issue.
3. Magnus of Mecklenburg-Schwerin (3 May 1815 – 25 April 1816) died in infancy.

• (in French) Hélène de Mecklembourg-Schwerin; Madame la duchesse d'Orléans; Nouvelle édition. Paris: Michel Lévy, 1859. DC 269 .O7 M34 1859