Rostral interstitial nucleus of medial longitudinal fasciculus

Rostral interstitial nucleus of medial longitudinal fasciculus
Rostral interstitial nucleus of medial longitudinal fasciculus
	Axial section through mid-brain. (Nucleus is not labeled, but MLF is "b", in red.)
Details
Identifiers
Latin	nucleus interstitialis
NeuroNames	516
NeuroLex ID	birnlex_1481
	Anatomical terms of neuroanatomy [edit on Wikidata]

The rostral interstitial nucleus of medial longitudinal fasciculus (riMLF) is a collection of neurons in the medial longitudinal fasciculus in the midbrain.^[1] It is responsible for mediating vertical conjugate eye movements (vertical gaze)^[1]^[2]^: 458.e1 and vertical saccades.^[3]^: 122 It mostly projects efferents to the ipsilateral oculomotor and trochlear nuclei.^[2]^: 458.e1

To mediate downgaze, it projects efferents to the ipsilateral oculomotor nucleus and trochlear nucleus; mediate upgaze,^[2]^: 777-778 it projects efferents to the contralateral aforementioned nuclei^[3]^: 122^{[additional citation(s) needed]} through the posterior commissure.^[2]^: 777-778

It is one of the accessory oculomotor nuclei.^[3]^: 156

Anatomy

Structure

The riMLF is a wing-shaped nucleus.^[2]^: 458.e1

The riMLF contains two populations of neurons: excitatory burst neurons mediating vertical gaze/saccades, as well as omnipause neurons which are functionally similar to those mediating horizontal gaze.^[2]^: 1464.e17

Relations

It is situated at the caudal extremity of the mesencephalon^[1] at its junction with the telencephalon,^[3]^: 156 at the level of the superior colliculus.^[1] It is situated dorsal to the rostral extremity of the red nucleus, and rostral to the interstitial nucleus of Cajal.^[2]^: 458.e1

Clinical significance

Lesions of the riMLF may impair vertical gaze completely, or predominately impair downgaze.^[2]^: 778 Lesions of the posterior commissure meanwhile disrupt upgaze.^[2]^: 1464.e17

References

^ ^a ^b ^c ^d Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. p. 310. ISBN 978-1-118-67746-9.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Standring, Susan (2020). Gray's Anatomy: The Anatomical Basis of Clinical Practice (42th ed.). New York: Elsevier. ISBN 978-0-7020-7707-4. OCLC 1201341621.
^ ^a ^b ^c ^d Kiernan, John A.; Rajakumar, Nagalingam (2013). Barr's The Human Nervous System: An Anatomical Viewpoint (10th ed.). Philadelphia: Wolters Kluwer Lippincott Williams & Wilkins. ISBN 978-1-4511-7327-7.

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[Patestas-2016-1] Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. p. 310. ISBN 978-1-118-67746-9.

[Standring-2020-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Standring, Susan (2020). Gray's Anatomy: The Anatomical Basis of Clinical Practice (42th ed.). New York: Elsevier. ISBN 978-0-7020-7707-4. OCLC 1201341621.

[Kiernan-2013-3] Kiernan, John A.; Rajakumar, Nagalingam (2013). Barr's The Human Nervous System: An Anatomical Viewpoint (10th ed.). Philadelphia: Wolters Kluwer Lippincott Williams & Wilkins. ISBN 978-1-4511-7327-7.

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