Small nucleolar RNA R24

Small nucleolar RNA R24
Predicted secondary structure and sequence conservation of snoR24
Identifiers
Symbol	snoR24
Rfam	RF00132
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe

In molecular biology, Small nucleolar RNA R24 (also known as snoRNA R24) is a non-coding RNA (ncRNA) molecule identified in plants which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

R24 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^[1][2]

snoR24 was originally identified in Arabidopsis thaliana and is proposed to acts as a methylation guide for 18S ribosomal RNA (rRNA) in plants.^[3]

• Page for Small nucleolar RNA R24 at Rfam
• plant snoRNA database

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