He played in the first game at Boston's Fenway Park, on April 20, 1912, during which he had five hits, including two doubles. In the 1912 World Series, he drove in the winning run for the Red Sox in Game One, and scored the Series-winning run in the tenth inning of Game Eight.
After his major league career ended, Yerkes continued to play on and off in minor league baseball until 1923, mostly with the Indianapolis Indians. He then began a career as a manager, working with various minor league teams between 1924 and 1947.