Cingrani worked with Rice's coaches to change his mechanics during the offseason, which resulted in improved fastball velocity: from 86 miles per hour (138 km/h) before the changes to 90 to 94 miles per hour (145–151 km/h) after. However, he did not make the Owls' starting rotation due to the inconsistency of his off-speed pitches.[4] Converted into a relief pitcher for his senior season, Cingrani tied the school record with 12 saves. He also had a 4–2 win–loss record, a 1.74 ERA and struck out 66 batters while walking only 10 in 57 innings pitched.[5]
After starter Johnny Cueto was placed on the disabled list, Cingrani was called up by the Reds on April 18, 2013, to take the starting rotation spot for Cueto until Cueto was reactivated.[12] In July, Cingrani bounced between the rosters of the Cincinnati Reds and the Arizona League Reds. He was optioned to the AZL Reds on July 17, recalled on July 23, optioned on July 24, and recalled on July 28. He did not appear in any games for the AZL Reds during this period.[13]
During spring training in 2015, the Reds announced that Cingrani would serve as a relief pitcher during the season.[14]
The next two seasons, Cingrani pitched to ERAs of 5.67 and 4.14 respectively.[15] The 2017 season did not start any better for Cingrani, posting a 5.40 ERA while playing for the Cincinnati Reds.[15]
Los Angeles Dodgers
Cingrani was traded to the Los Angeles Dodgers on July 31, 2017, in exchange for outfielder Scott Van Slyke and minor league catcher Hendrik Clementina.[16]
Cingrani pitched in 191⁄3 innings in 22 games for the Dodgers during the 2017 season, posting a 2.79 ERA. In the postseason, he made two appearances in each of the NLDS and NLCS, giving up no runs and allowing only a single and a hit by pitch.[15] He appeared in three games during the 2017 World Series, allowing one run to score on two hits with two strikeouts in three innings.[15] After the season, he signed a one-year, $2.3 million, contract with the Dodgers for 2018, to avoid salary arbitration.[17] On May 4, 2018, against the San Diego Padres at Estadio de Béisbol Monterrey, Cingrani was one of four pitchers involved in a combined no-hitter as the Dodgers won 4–0.[18] Cingrani was limited to just 30 appearances on the season, posting a record of 1–2 with an ERA of 4.76. In the second half of 2018, Cingrani suffered a shoulder injury that kept him out for the rest of the season. In March 2019, he suffered a recurrence of the injury and the Dodgers shut him down for Spring Training. On May 4, he started a rehab assignment with the High-A Rancho Cucamonga Quakes team.[19] On May 8, his rehab assignment was moved to Triple-A Oklahoma City.[20] In June 2019, Cingrani underwent arthroscopic surgery to fix a left labrum tear and was ruled out for the season.[21]
St. Louis Cardinals
On July 31, 2019, the Dodgers traded Cingrani and Jeffry Abreu to the St. Louis Cardinals in exchange for Jedd Gyorko, international cap space, and cash considerations.[22] On October 31, 2019, Cingrani became a free agent.
On June 28, 2021, Cingrani's contract was purchased by the Chicago Cubs organization.[25]
Cingrani appeared in 12 games for the Triple-A Iowa Cubs, posting a 3.60 ERA with 15 strikeouts. On August 25, Cingrani was released by the Cubs.[26]