Toomsuba is in eastern Lauderdale County, 13 miles (21 km) east of Meridian, the county seat. U.S. Routes 80 and 11 pass through the community as its main street. Interstate Highways 20 and 59 run along the southern edge of the community, with access from Exit 165 (Will Garrett Road). I-20 and I-59 lead west to Meridian and northeast 77 miles (124 km) to Tuscaloosa, Alabama, while U.S. Route 11 and 80 lead west to Meridian and east 9 miles (14 km) to their split near Cuba, Alabama.
According to the U.S. Census Bureau, the Toomsuba CDP has a total area of 5.0 square miles (13.0 km2), of which 4.7 square miles (12.1 km2) are land and 0.3 square miles (0.8 km2), or 6.27%, are land.[6] In addition to the Toomsuba town center at the crossroads of US 11/80 with Will Garrett Road and Lauderdale–Toomsuba Road, the CDP contains residential development around Bailey Lake, a reservoir just west of the town center.
^Note: the US Census treats Hispanic/Latino as an ethnic category. This table excludes Latinos from the racial categories and assigns them to a separate category. Hispanics/Latinos can be of any race.[9][10]