The Winona Commercial Historic District comprises six downtown blocks along 3rd Street in Winona, Minnesota, United States. It comprises 65 contributing properties mostly built in the 1880s and 1890s.[2] The district was listed on the National Register of Historic Places in 1998 for having local significance in the theme of commerce.[3] It was nominated for reflecting the prosperity of a river and rail town that grew into southeast Minnesota's leading commercial center of the late 19th century.[2]