In December 2020, PSG sporting director Leonardo terminated Tuchel's contract.[7] Tuchel's staff, including Lőw, were let go as well.[7] Lőw went with Tuchel when the German was hired by Premier League club Chelsea the following month.[8] He was in charge of Chelsea's Club World Cup semi-final as Tuchel was isolating after a positive COVID-19 test.
Lőw left Chelsea after Tuchel was dismissed as head coach. In March 2023, shortly after the latter had been appointed head coach of Bayern Munich, Lőw joined him as an assistant.[9] Later that year, on 20 September, he managed Bayern's Champions League opening match against Manchester United, leading the team to a 4–3 victory in the absence of head coach Tuchel, who was suspended.[10]