Alfentaniloa[1]opioide jatorriko farmako analgesiko sintetikoa da, iraupen laburrekoa eta, oro har, bide parenteraletik erabiltzen dutena. Kirurgian anestesiko gisa erabiltzen dute. Fentaniloaren antzekoa da, baina % 10-20ko potentziarekin bakarrik.
Mota bereko beste farmako batzuekin alderatuta, alfentaniloak konplikazio kardiobaskular gutxiago eragiten ditu, baina arnas depresio handiagoa eragiten du. Bere batez besteko bizitza laburragoa dela eta, familiako beste analgesiko batzuk baino gehiago erabiltzen dute, azkarrago ezabatzen denez, baita iraupen luzeko ebakuntza kirurgikoetan ere. Janssen Pharmaceuticak 1976an garatu zuen.
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