CYP2C8
P450 2C8 zitokromoa (CYP2C8) P450 zitokromoaren proteina-multzoko entzima da. Entzima horrek zerikusia du, besteak beste, paclitaxel, repaglinida, rosiglitazona eta zeribastatina botiken metabolismoan. Lehen, "P450 zitokromoa, IIC subfamilia (mefenitoina 4-hidroxilasa), 8 polipeptidoa" deitzen zitzaion.[7]
CYP2C8aren inhibitzaileak
Identifikaturiko inhibitzaile indartsuena leukotrieno-hartzailearen antagonista izan zen, montelukast. CYP2C8aren beste inhibitzaile batzuk klase terapeutiko ugariren bidez identifikatu ziren, klase bakar bat nagusitu gabe. Inhibitzaile indartsu horien artean daude candesartan zilexetiloa (txirristako profarmakoa), zafirlukast, clotrimazola, felodipinoa eta mometasonaren furoatoa.[8]
Erreferentziak
- ↑ Genetikoki lotutako gaixotasunak CYP2C8ikusi/editatu erreferentziak Wikidatan. .
- ↑ Fisikoki elkarreragiten duten drogak cytochrome P450 family 2 subfamily C member 8ikusi/editatu erreferentziak Wikidatan. .
- ↑ a b c GRCh38: Ensembl release 89: ENSG00000138115 - Ensembl, May 2017
- ↑ a b c GRCm38: Ensembl release 89: ENSMUSG00000025003 – Ensembl, May 2017
- ↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ genenames.org. CYP2C8. .
- ↑ Walsky, RL; Gaman EA; Obach RS.. (Jan de 2005). «Examination of 209 drugs for inhibition of cytochrome P450 2C8.» J. Clin. Pharmacol 45 (1): 68..
Kanpo estekak
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Datuak: Q14916190
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