SRGAP2
SLIT-ROBO Rho GTPasa-aktibatze proteina 2 (srGAP2), edo formina-lokailu proteina 2 (FNBP2), ugaztunen proteina bat da, SRGAP2 genea kodetzen duena[5][6]. Neuronen migrazioan eta diferentziazioan parte hartzen du[7] eta paper kritikoa du sinapsiaren garapenean[8], garunaren masan eta neurona kortikalen kopuruan[9]. srGAP2ren deserregulazioak zelula-zelua urruntzea inhibitzen du, eta zelula-zelua kontaktua indartzen du.
SRGAP2k dimeroa du F-BAR domeinuan. SRGAP2C, bertsio laburragoa dena lehen Homininietan eta gizakiengan aurkitzen dena, F-BAR domeinu bakarra du, ekintzaren antagonista dena. Neurona batzuen heltzea geldotzen du, eta bizkarrezurreko neuronen dentsitatea handitzen du[10]. SRGAP2 minbizi batzuen garapenarekin ere lotuta egon liteke[11].
Erreferentziak
- ↑ a b c GRCh38: Ensembl release 89: ENSG00000266028 - Ensembl, May 2017
- ↑ a b c GRCm38: Ensembl release 89: ENSMUSG00000026425 – Ensembl, May 2017
- ↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Madura, Tomas; Yamashita, Toshihide; Kubo, Tateki; Tsuji, Lyuji; Hosokawa, Ko; Tohyama, Masaya. (2004-04-07). «Changes in mRNA of Slit–Robo GTPase-activating protein 2 following facial nerve transection» Molecular Brain Research 123 (1): 76–80. doi:. ISSN 0169-328X. (kontsulta data: 2025-03-07).
- ↑ (Ingelesez) Wong, Kit; Ren, Xiu-Rong; Huang, Yang-Zhong; Xie, Yi; Liu, Guofa; Saito, Harumi; Tang, Hao; Wen, Leng et al.. (2001-10-19). «Signal Transduction in Neuronal Migration: Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway» Cell 107 (2): 209–221. doi:. ISSN 0092-8674. PMID 11672528. (kontsulta data: 2025-03-07).
- ↑ (Ingelesez) Guerrier, Sabrice; Coutinho-Budd, Jaeda; Sassa, Takayuki; Gresset, Aurélie; Jordan, Nicole Vincent; Chen, Keng; Jin, Wei-Lin; Frost, Adam et al.. (2009-09-04). «The F-BAR Domain of srGAP2 Induces Membrane Protrusions Required for Neuronal Migration and Morphogenesis» Cell 138 (5): 990–1004. doi:. ISSN 0092-8674. PMID 19737524. PMC PMC2797480. (kontsulta data: 2025-03-07).
- ↑ (Ingelesez) Charrier, Cécile; Joshi, Kaumudi; Coutinho-Budd, Jaeda; Kim, Ji-Eun; Lambert, Nelle; de Marchena, Jacqueline; Jin, Wei-Lin; Vanderhaeghen, Pierre et al.. (2012-05-11). «Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation» Cell 149 (4): 923–935. doi:. ISSN 0092-8674. PMID 22559944. PMC PMC3357949. (kontsulta data: 2025-03-07).
- ↑ Tiwary, Basant K.. (2016-03-01). «Evolution of the SRGAP2 Gene Is Linked to Intelligence in Mammals» Biomedicine Hub 1 (1): 1–12. doi:. ISSN 2296-6870. PMID 31988884. PMC PMC6945801. (kontsulta data: 2025-03-07).
- ↑ InterPro. (2017-09-22). «What's ape» proteinswebteam.github.io (kontsulta data: 2025-03-07).
- ↑ Li, Yan; Qiao, Lu; Bai, Yuru; Xiao, Cailan; Wu, Jian; Gao, Xiaoliang; Qiao, Chenyang; Shi, Yongquan et al.. (2021-07-15). «Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma» Life Sciences 277: 119592. doi:. ISSN 0024-3205. (kontsulta data: 2025-03-07).
Kanpo estekak
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Datuak: Q18037135
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