Saxagliptina
| Saxagliptina | |
|---|---|
 | |
| Formula kimikoa | C18H25N3O2 |
| SMILES kanonikoa | 2D eredua |
| SMILES isomerikoa | C1[C@@H]2C[C@@H]2N([C@@H]1C#N)C(=O)[C@H](C34CC5CC(C3)CC(C5)(C4)O)N |
| MolView | 3D eredua |
| Mota | konposatu kimiko |
| Masa molekularra | 315,194677 Da |
| Erabilera | |
| Konposatu aktiboa | Onglyza (en)  |
| Elkarrekintza | Dipeptidyl peptidase 4 (en) |
| Rola | dipeptidyl peptidase-4 inhibitors (en) |
| Identifikatzaileak | |
| InChlKey | QGJUIPDUBHWZPV-SGTAVMJGSA-N |
| CAS zenbakia | 361442-04-8 |
| ChemSpider | 9419005 |
| PubChem | 11243969 |
| Reaxys | 10201614 |
| Gmelin | 71272 |
| ChEMBL | CHEMBL385517 |
| RxNorm | 1546030 eta 857974 |
| Human Metabolome Database | HMDB0015634 |
| UNII | 8I7IO46IVQ |
| NDF-RT | N0000179814 |
| KEGG | D08996 |
Saxagliptina konposatu organikoa da, C18H25N3O2 formula duena, adamantanoaren deribatua eta amiden klasekoa. Solidoa da[1].
Sintesia
Saxagliptina beheko eskemaren arabera sintetizatzen da[2].
Erabilera
Saxagliptina dipeptidil peptidasa-4aren inhibitzailea da eta 2 motako diabetea tratatzeko usatzen da. Espainian Tesavel merkaturatzen da[3]. Frantzian Onglyza markarekin eta botika generiko gisa merkaturatzen da[4]. Pilula gisa hartzen da.
Albo-ondorioak
Saxagliptinaren albo-ondorio ohikoenak hauek dira: gernu-aparatuko infekzioa, gastroenteritisa, sinusitisa; zorabioa, zefalea; abdomeneko mina, beherakoa, goragaleak; azaleko erupzioa eta nekea[3].
Erreferentziak
- ↑ (Ingelesez) PubChem. «Saxagliptin» pubchem.ncbi.nlm.nih.gov (kontsulta data: 2025-11-02).
- ↑ Savage, Scott A.; Jones, Gregory S.; Kolotuchin, Sergei; Ramrattan, Shelly Ann; Vu, Truc; Waltermire, Robert E.. (2009-11-20). «Preparation of Saxagliptin, a Novel DPP-IV Inhibitor» Organic Process Research & Development 13 (6): 1169–1176. doi:. ISSN 1083-6160. (kontsulta data: 2025-11-02).
- ↑ a b (Gaztelaniaz) Spain, Vidal Vademecum. «Vademecum.es - Su fuente de conocimiento farmacológico» Vademecum.es (kontsulta data: 2025-11-02).
- ↑ Saxagliptine. .
| Autoritate kontrola |
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Datuak: Q3121121
Multimedia: Saxagliptin / Q3121121
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Index:
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