TOP2B

TOP2B
Egitura erabilgarria
PDB	Ortologoaren bilaketa: PDBe RCSB
PDB ID kodeen zerrenda
	3QX3, 4G0U, 4G0V, 4G0W, 4J3N
Identifikatzaileak
Aliasak	TOP2B (HUGO), TOPIIB, top2beta, topoisomerase (DNA) II beta, DNA topoisomerase II beta, BILU
Kanpoko IDak	OMIM: 126431 MGI: 98791 HomoloGene: 134711 GeneCards: TOP2B OMA: TOP2B - orthologs
Genearen kokapena (gizakia)
	Kromosoma: 3 (gizakia)
Amaiera	25.664.907 bp
Genearen kokapena (sagua)
	Kromosoma: 14 (sagua)
Amaiera	6.104.584 bp
RNA adierazpen eredua
	Adierazpen ohikoena
	ganglionic eminence ; ; ventricular zone ; ; endothelial cell ; ; Orpazurda; ; cerebellar cortex ; ; cerebellar hemisphere ; ; right hemisphere of cerebellum ; ; retinal pigment epithelium ; ; epithelium of colon ; ; ondeste;
	Adierazpen ohikoena
	ventricular zone ; ; ganglionic eminence ; ; tail of embryo ; ; medial ganglionic eminence ; ; genital tubercle ; ; timo; ; abdominal wall ; ; dermis; ; Kondilo; ; lobe of cerebellum ;
	Erreferentziazko adierazpen datu gehiago
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ; nucleotide binding ; DNA binding ; histone deacetylase binding ; chromatin binding ; isomerase activity ; metal ion binding ; DNA topoisomerase activity ; protein C-terminus binding ; protein heterodimerization activity ; enzyme binding ; ATP binding ; protein kinase C binding ; ribonucleoprotein complex binding ;
Zelularen osagaia	zitosol ; Nukleoplasma ; heterokromatina ; Nukleolo ; zelula nukleo ; zitoplasma ; ribonucleoprotein complex ; viral integration complex ;
Prozesu biologikoa	resolution of meiotic recombination intermediates ; axonogenesis ; DNA metabolic process ; neuron migration ; forebrain development ; mitotic DNA integrity checkpoint signaling ; sister chromatid segregation ; DNA topological change ; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate ;
	Iturburuak: : Amigo / QuickGO
Ortologoak
	7155
	21974
	ENSG00000077097
	ENSMUSG00000017485
	Q02880
	Q64511
	NM_001068; NM_001330700
	NM_009409
	NP_001059; NP_001317629
	NP_033435
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

Topoisomerasa 2 beta (TOP2B) TOP2B geneak gizakietan kodetutako proteina bat da.^[5]^[6]

Gene horrek DNAren topoisomerasa bat kodetzen du, transkripzio genetikoan DNAren egoera topolologikoak kontrolatzen eta aldatzen dituen entzima. Entzima nuklear bat da, kromosomaren kondentsazioa, kromatiden bereizketa eta DNA transkrizioan eta erreplikazioan tortsio-tentsioa askatzea bezalako prozesuetan inplikatua dagoena. DNAren bi harien haustura iragankorra eta lotura katalizatzen ditu, eta, horri esker, hariak batetik bestera pasatzen dira, eta, horrela, DNAren topologia aldatzen da. Entzima horren bi forma deskribatu dira, ziurrenik genea bikoizteko gertaera baten emaitza gisa. Forma hori kodetzen duen genea, beta, 3. kromosoman dago, eta alfa-forma 17. kromosoman. TOP2B geneak zenbait minbiziaren kontrako farmakoen jomuga gisa jarduten du, eta gene horren mutazio mota batzuk botikekiko erresistentziaren garapenarekin lotu dira. Entzima horren jarduera murriztuak zeregin bat izan dezake ataxia telangiektasian. Gene horren transkripzio-aldaera bi deskribatu dituzte, baina bigarren aldaera ez dute erabat karakterizatu.^[7]

Elkarreraginak

TOP2B proteinak ondokoekin elkarreragiteko gai dela erakutsi du:

Erreferentziak

↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077097 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017485 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tan KB, Dorman TE, Falls KM, Chung TD, Mirabelli CK, Crooke ST, Mao J. (1992ko urtarrila). «Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively» Cancer Res 52 (1): 231–4. PMID 1309226..
↑ Jenkins JR, Ayton P, Jones T, Davies SL, Simmons DL, Harris AL, Sheer D, Hickson ID. (1993ko urtarrila). «Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24» Nucleic Acids Res 20 (21): 5587–92. PMID 1333583..
↑ (Ingelesez) Entrez Gene: TOP2B topoisomerase (DNA) II beta 180kDa. .
↑ (Ingelesez) Hirochika Kitagawa, Fujiki Ryoji, Yoshimura Kimihiro, Mezaki Yoshihiro, Uematsu Yoshikatsu, Matsui Daisuke, Ogawa Satoko, Unno Kiyoe, Okubo Mataichi, Tokita Akifumi, Nakagawa Takeya, Ito Takashi, Ishimi Yukio, Nagasawa Hiromichi, Matsumoto Toshio, Yanagisawa Junn, Kato Shigeaki. (2003ko ekaina). «The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome» Cell 113 (7): 905–17. ISSN 0092-8674. PMID 12837248..
↑ ^a ^b Tsai S C, Valkov N, Yang W M, Gump J, Sullivan D, Seto E. (2000ko azaroa). «Histone deacetylase interacts directly with DNA topoisomerase II» Nat. Genet. 26 (3): 349–53. doi:10.1038/81671. ISSN 1061-4036. PMID 11062478..
↑ Johnson C A, Padget K, Austin C A, Turner B M. (2001eko otsaila). «Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis» J. Biol. Chem. 276 (7): 4539–42. doi:10.1074/jbc.C000824200. ISSN 0021-9258. PMID 11136718..
↑ Nakano H; Yamazaki T; Miyatake S; Nozaki N; Kikuchi A; Saito T. (1996ko martxoa). «Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex» J. Biol. Chem. 271 (11): 6483–9. ISSN 0021-9258. PMID 8626450..
↑ Mao Y, Desai S D, Liu L F. «SUMO-1 conjugation to human DNA topoisomerase II isozymes» J. Biol. Chem. 275 (34): 26066–73. doi:10.1074/jbc.M001831200. ISSN 0021-9258. PMID 10862613..
↑ Cowell I G, Okorokov A L, Cutts S A, Padget K, Bell M, Milner J, Austin C A. (2000ko otsaila). «Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53» Exp. Cell Res. 255 (1): 86–94. doi:10.1006/excr.1999.4772. ISSN 0014-4827. PMID 10666337..

Kanpo estekak

Datuak: Q18032067

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077097 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017485 – Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1309226-5] Tan KB, Dorman TE, Falls KM, Chung TD, Mirabelli CK, Crooke ST, Mao J. (1992ko urtarrila). «Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively» Cancer Res 52 (1): 231–4. PMID 1309226..

[pmid1333583-6] Jenkins JR, Ayton P, Jones T, Davies SL, Simmons DL, Harris AL, Sheer D, Hickson ID. (1993ko urtarrila). «Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24» Nucleic Acids Res 20 (21): 5587–92. PMID 1333583..

[entrez-7] (Ingelesez) Entrez Gene: TOP2B topoisomerase (DNA) II beta 180kDa. .

[pmid12837248-8] (Ingelesez) Hirochika Kitagawa, Fujiki Ryoji, Yoshimura Kimihiro, Mezaki Yoshihiro, Uematsu Yoshikatsu, Matsui Daisuke, Ogawa Satoko, Unno Kiyoe, Okubo Mataichi, Tokita Akifumi, Nakagawa Takeya, Ito Takashi, Ishimi Yukio, Nagasawa Hiromichi, Matsumoto Toshio, Yanagisawa Junn, Kato Shigeaki. (2003ko ekaina). «The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome» Cell 113 (7): 905–17. ISSN 0092-8674. PMID 12837248..

[pmid11062478-9] Tsai S C, Valkov N, Yang W M, Gump J, Sullivan D, Seto E. (2000ko azaroa). «Histone deacetylase interacts directly with DNA topoisomerase II» Nat. Genet. 26 (3): 349–53. doi:10.1038/81671. ISSN 1061-4036. PMID 11062478..

[pmid11136718-10] Johnson C A, Padget K, Austin C A, Turner B M. (2001eko otsaila). «Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis» J. Biol. Chem. 276 (7): 4539–42. doi:10.1074/jbc.C000824200. ISSN 0021-9258. PMID 11136718..

[pmid8626450-11] Nakano H; Yamazaki T; Miyatake S; Nozaki N; Kikuchi A; Saito T. (1996ko martxoa). «Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex» J. Biol. Chem. 271 (11): 6483–9. ISSN 0021-9258. PMID 8626450..

[pmid10862613-12] Mao Y, Desai S D, Liu L F. «SUMO-1 conjugation to human DNA topoisomerase II isozymes» J. Biol. Chem. 275 (34): 26066–73. doi:10.1074/jbc.M001831200. ISSN 0021-9258. PMID 10862613..

[pmid10666337-13] Cowell I G, Okorokov A L, Cutts S A, Padget K, Bell M, Milner J, Austin C A. (2000ko otsaila). «Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53» Exp. Cell Res. 255 (1): 86–94. doi:10.1006/excr.1999.4772. ISSN 0014-4827. PMID 10666337..

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TOP2B

Elkarreraginak

Erreferentziak

Kanpo estekak

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