AIDS huwa l-akronimu ta' Acquired Immune Deficiency Syndrome jew, aħjar bil-Malti, Sindrome ta' immunodefiċjenza akkwiżita u tiddefinixxi is-sindrome sseħħ minħabba n-nuqqas ta' linfoċiti T (T lymphocytes). Fost il-manifestazzjonijiet insibu infezzjonijiet rikorrenti minn mikroorganiżmi li normalment ma jkunux patoġeniċi (ċioè, ma jikkawżawx mard jew ħsara), kif ukoll żieda drastika fin-numru ta' tumuri, kemm dawk ta' natura komuni, kif ukoll dawk karatteristiċi ta' pazzjenti immunokompromessi (li għandhom sistema immunitarja difettuża) u wkoll tumuri partikolari u rari li jimmanifestaw ruħhom biss f'din is-sindrome, bħal ngħidu aħna Kapsosi sarcoma. Illum il-ġurnata nafu li l-AIDS hija kkawżata mill-virus HIV.
Iż-Żigarella Ħamra hija s-simbolu universali ta' solidarjetà lejn il-persuni sjeropożittivi u wkoll lejn dawk li jgħixu bl-AIDS
Attwalment is-sindrome hija inkurabbli, jiġifieri mhux possibbli li jiġi eradikat totalment il-virus mill-ospite. Iżda t-terapija eżistenti, li hija ħafna iktar aħjar u tollerata minn dik użata fis-snin '80, jirnexxila tnaqqas il-viremja b'mod effettiv ħafna. L-andament kliniko-patoloġiku tas-sindrome huwa estermament varjabbli bejn l-individwi affettwati, u dan minħabba l-fatt li l-progressjoni ta' l-infezzjoni tiddependi fuq fatturi ġenetiċi kemm tal-virus (Campbell et al., 2004; Campbell et al., 2005; Senkaali et al., 2005) kif ukoll ta' l-ospite (Clerici et al., 1996; Morgan et al., 2002a; Tang et al., 2003), u tiġi wkoll affettwata mill-kundizzjonijiet iġeniċi u ko-infezzjonijiet (Morgan et al., 2002b; Lawn et al., 2004).
Fil-pajjiżi fejn il-kura anti-retrovirali u anti-neoplastika, kif ukoll kura għall-infezzjonijiet opportunistiċi, huma disponibili, il-mortalità ta' l-AIDS tiġi ridotta ħafna (Palella et al., 1998). Dawn però għandhom ħafna effetti kollaterali (Montessori et al., 2004), u hemm ċans li l-pazzjenti jiżviluppaw reżistenza għall-farmaċi jew inkella ma jkollhomx aċċess għal din it-tip ta' mediċina.
Bibljografija
Becker, S., Dezii, C. M., Burtcel, B., Kawabata, H. and Hodder, S. (2002) Young HIV-infected adults are at greater risk for medication nonadherence. MedGenMed. 4, 21 PMID 12466764
Campbell, G. R., Pasquier, E., Watkins, J., Bourgarel-Rey, V., Peyrot, V., Esquieu, D., Barbier, P., de Mareuil, J., Braguer, D., Kaleebu, P., Yirrell, D. L. and Loret E. P. (2004) The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. J. Biol. Chem.279, 48197-48204 PMID 15331610
Campbell, G. R., Watkins, J. D., Esquieu, D., Pasquier, E., Loret, E. P., Spector, S. A. (2005) The C terminus of HIV-1 Tat modulates the extent of CD178-mediated apoptosis of T cells. J. Biol. Chem.280, 38376-39382 PMID 16155003
Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A, Martin MA. (1986) Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol.59, 284-291 PMID 3016298
Aldrovandi GM, Feuer G, Gao L, Jamieson B, Kristeva M, Chen IS, Zack JA. (1993) The SCID-hu mouse as a model for HIV-1 infection. Nature363, 732-736 PMID 8515816
Baumann E, Bethell T, Bialy H, Duesberg PH, Farber C, Geshekter CL, Johnson PE, Maver RW, Schoch R, Stewart GT, et al. (1995) AIDS proposal. Group for the Scientific Reappraisal of the HIV/AIDS Hypothesis. Science267, 945-946 PMID 7863335
Busch MP, Eble BE, Khayam-Bashi H, Heilbron D, Murphy EL, Kwok S, Sninsky J, Perkins HA, Vyas GN. (1991) Evaluation of screened blood donations for human immunodeficiency virus type 1 infection by culture and DNA amplification of pooled cells. N Engl J Med325, 1-5 PMID 2046708
Canaani E, Tronick SR, Robbins KC, Andersen PR, Dunn CY, Aaronson SA. (1980) Cellular origin of the transforming gene of Moloney murine sarcoma virus. Cold Spring Harb Symp Quant Biol.44 Pt 2, 727-734 PMID 6253207
Ciesielski CA, Marianos DW, Schochetman G, Witte JJ, Jaffe HW. (1994) The 1990 Florida dental investigation. The press and the science. Ann Intern Med121, 886-888 PMID 7978703
Duesberg PH. (1996a) Inventing the AIDS virus. Regnery Publishing, Inc.
Duesberg PH. (1996b) AIDS: Virus or Drug Induced?Springer
Papadopulos-Eleopulos E, Turner VF, Papadimitriou J, Page B, Causer D, Alfonso H, Mhlongo S, Miller T, Maniotis A, Fiala C. (2004) A critique of the Montagnier evidence for the HIV/AIDS hypothesis. Med Hypotheses63, 597-601 PMID 15325002
Galéa P and Chermann JC (1998) HIV as the cause of AIDS and associated diseases Genetica104, 133-142 PMID 10220906
Grisson RD, Chenine AL, Yeh LY, He J, Wood C, Bhat GJ, Xu W, Kankasa C, Ruprecht RM. (2004) Infectious molecular clone of a recently transmitted pediatric human immunodeficiency virus clade C isolate from Africa: evidence of intraclade recombination. J Virol.78, 14066-14069 PMID 15564517
Horton R. (1995) Will Duesberg now concede defeat? Lancet346, 656 PMID 7658817
Hirsch VM, Johnson PR. (1994) Pathogenic diversity of simian immunodeficiency viruses. Virus Res.32, 183-203 PMID 8067053
Jackson JB, Kwok SY, Sninsky JJ, Hopsicker JS, Sannerud KJ, Rhame FS, Henry K, Simpson M, Balfour HH Jr. (1990) Human immunodeficiency virus type 1 detected in all seropositive symptomatic and asymptomatic individuals. J Clin Microbiol.28, 16-19 PMID 2298875
Jaffe HW, Darrow WW, Echenberg DF, O'Malley PM, Getchell JP, Kalyanaraman VS, Byers RH, Drennan DP, Braff EH, Curran JW, et al. (1985) The acquired immunodeficiency syndrome in a cohort of homosexual men. A six-year follow-up study. Ann Intern Med.103, 210-214 PMID 2990275
Joag SV, Li Z, Foresman L, Stephens EB, Zhao LJ, Adany I, Pinson DM, McClure HM, Narayan O. (1996) Chimeric simian/human immunodeficiency virus that causes progressive loss of CD4+ T cells and AIDS in pig-tailed macaques. J. Virol.70, 3189-3197 PMID 8627799
Koch R. (1884) Mitt Kaiser Gesundh2, 1-88
Koch R. (1893) J. Hyg. Inf.14, 319-333
Liska V, Khimani AH, Hofmann-Lehmann R, Fink AN, Vlasak J, Ruprecht RM. (1999) Viremia and AIDS in rhesus macaques after intramuscular inoculation of plasmid DNA encoding full-length SIVmac239. AIDS Res Hum Retroviruses.15, 445-450 PMID 10195754
Locher CP, Barnett SW, Herndier BG, Blackbourn DJ, Reyes-Teran G, Murthy KK, Brasky KM, Hubbard GB, Reinhart TA, Haase AT, Levy JA. (1998) Human immunodeficiency virus-2 infection in baboons is an animal model for human immunodeficiency virus pathogenesis in humans. Arch Pathol Lab Med.122, 523-533 PMID 9625420
Monti-Bragadin C, Ulrich K. (1972) Rescue of the genome of the defective murine sarcoma virus from a non-producer hamster tumor cell line, PM-1, with murine and feline leukemia viruses as helpers. Int J Cancer9, 383-392 PMID 4339414
Nkengasong JN, Maurice C, Koblavi S, Kalou M, Yavo D, Maran M, Bile C, N'guessan K, Kouadio J, Bony S, Wiktor SZ, Greenberg AE. (1999) Evaluation of HIV serial and parallel serologic testing algorithms in Abidjan, Cote d'Ivoire. AIDS13, 109-117 PMID 10207552
Peebles PT, Gerwin BI, Scolnick EM. (1976) Murine sarcoma virus defectiveness: serological detection of only helper virus reverse transcriptase in sarcoma virus rescued from nonmurine S + L-cells. Virology70, 313-323 PMID 57666
Root-Bernstein R. (1993) Rethinking AIDS: the tragic cost of premature consensus. New York: Free Press
Samdal HH, Gutigard BG, Labay D, Wiik SI, Skaug K, Skar AG. (1996) Comparison of the sensitivity of four rapid assays for the detection of antibodies to HIV-1/HIV-2 during seroconversion. Clin Diagn Virol.7, 55-61 PMID 9077430
Silvester C, Healey DS, Cunningham P, Dax EM. (1995) Multisite evaluation of four anti-HIV-1/HIV-2 enzyme immunoassays. Australian HIV Test Evaluation Group. J Acquir Immune Defic Syndr Hum Retrovirol.8, 411-419 PMID 7882108
Sinoussi F, Mendiola L, Chermann JC. (1973) Purification and partial differentiation of the particles of murine sarcoma virus (M. MSV) according to their sedimentation rates in sucrose density gradients. Spectra4,237-243
Tebit DM, Zekeng L, Kaptue L, Krausslich HG, Herchenroder O. (2003) Construction and characterisation of a full-length infectious molecular clone from a fast replicating, X4-tropic HIV-1 CRF02.AG primary isolate. Virology313, 645-652 PMID 12954230
Toplin I. (1973) Tumor Virus Purification using Zonal Rotors. Spectra4, 225-235
Urassa W, Godoy K, Killewo J, Kwesigabo G, Mbakileki A, Mhalu F, Biberfeld G. (1999) The accuracy of an alternative confirmatory strategy for detection of antibodies to HIV-1: experience from a regional laboratory in Kagera, Tanzania. J Clin Virol.14, 25-29 PMID 10548127
van den Berg H, Gerritsen EJ, van Tol MJ, Dooren LJ, Vossen JM. (1994) Ten years after acquiring an HIV-1 infection: a study in a cohort of eleven neonates infected by aliquots from a single plasma donation. Acta Paediatr.83, 173-178 PMID 8193497
Weiss RA, Jaffe HW. (1990) Duesberg, HIV and AIDS. Nature345, 659-660 PMID 2163025
Cayley, W. E. Jr. (2004) Effectiveness of condoms in reducing heterosexual transmission of HIV. Am. Fam. Physician. 70, 1268-1269 PMID 15508535
Clerici, M., Balotta, C., Meroni, L., Ferrario, E., Riva, C., Trabattoni, D., Ridolfo, A., Villa, M., Shearer, G.M., Moroni, M. and Galli, M. (1996) Type 1 cytokine production and low prevalence of viral isolation correlate with long-term non progression in HIV infection. AIDS Res. Hum. Retroviruses.12, 1053-1061 PMID 8827221
Decker, C. F. and Lazarus, A. (2000) Tuberculosis and HIV infection. How to safely treat both disorders concurrently. Postgrad Med. 108, 57-60, 65-68 PMID 10951746
Dias, S. F., Matos, M. G., Goncalves, A. C. (2005) Preventing HIV transmission in adolescents: an analysis of the Portuguese data from the Health Behaviour School-aged Children study and focus groups. Eur. J. Public Health15, 300-304 PMID 15941747
Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK; Panel on Clinical Practices for Treatment of HIV. (2002) Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Ann Intern Med.137, 381-433 PMID 12617573
Feldman, C. (2005) Pneumonia associated with HIV infection. Curr Opin Infect Dis.18, 165-170 PMID 15735422
Gao, F., et al. (1999) Origin of HIV-1 in the Chimpanzee Pan troglodytes troglodytes. Nature397, 436–441 PMIID 9989410
Gray F, Adle-Biassette H, Chrétien F, Lorin de la Grandmaison G, Force G, Keohane C. (2001) Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments. Clin. Neuropathol.20, 146-155 PMID 11495003
Guerrant, R. L., Hughes, J. M., Lima, N. L., Crane, J. (1990) Diarrhea in developed and developing countries: magnitude, special settings, and etiologies. Rev Infect Dis.12 Suppl 1, S41-50 PMID 2406855
Guss, D. A. (1994a) The acquired immune deficiency syndrome: an overview for the emergency physician, Part 1. J. Emerg. Med.12, 375-384 PMID 8040596
Guss, D. A. (1994b) The acquired immune deficiency syndrome: an overview for the emergency physician, Part 2. J. Emerg. Med.12, 491-497 PMID 7963396
Heaton RK, Grant I, Butters N, White DA, Kirson D, Atkinson JH, McCutchan JA, Taylor MJ, Kelly MD, Ellis RJ, et al. (1995) The HNRC 500--neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center. J. Int. Neuropsychol. Soc.1, 231-251 PMID 9375218
Holmes, C. B., Losina, E., Walensky, R. P., Yazdanpanah, Y., Freedberg, K. A. (2003) Review of human immunodeficiency virus type 1-related opportunistic infections in sub-Saharan Africa. Clin Infect Dis.36 656-662 PMID 12594648
Laga, M., Nzila, N., Goeman, J. (1991) The interrelationship of sexually transmitted diseases and HIV infection: implications for the control of both epidemics in Africa. AIDS5 Suppl 1, S55-S63 PMID 1669925
Lawn, S. D. (2004) AIDS in Africa: the impact of coinfections on the pathogenesis of HIV-1 infection. J. Infect.Dis.48, 1-12 PMID 14667787
Luft, B. J. and Chua, A. (2000) Central Nervous System Toxoplasmosis in HIV Pathogenesis, Diagnosis, and Therapy. Curr. Infect. Dis. Rep.2, 358-362 PMID 11095878
Marx, J. L. (1982) New disease baffles medical community. Science217, 618-621 PMID 7089584
MMWR weekly (1992) 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. December 18, 41 (RR17), 001
Montessori, V., Press, N., Harris, M., Akagi, L., Montaner, J. S. (2004) Adverse effects of antiretroviral therapy for HIV infection. CMAJ170, 229-238 PMID 14734438
Morgan, D., Mahe, C., Mayanja, B. and Whitworth, J. A. (2002a) Progression to symptomatic disease in people infected with HIV-1 in rural Uganda: prospective cohort study. BMJ324, 193-196 PMID 11809639
Morgan, D., Mahe, C., Mayanja, B., Okongo, J. M., Lubega, R. and Whitworth, J. A. (2002b) HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries? AIDS16, 597-6032 PMID 11873003
Orendi JM, Boer K, van Loon AM, Borleffs JC, van Oppen AC, Boucher CA. (1998) Vertical HIV-I-transmission. I. Risk and prevention in pregnancy. Ned. Tijdschr. Geneeskd.142, 2720-2724 PMID 10065235
Palella, F. J. Jr, Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., Aschman, D. J., Holmberg, S. D. (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N. Engl. J. Med.338 853-860 PMID 9516219
Rothenberg, R. B., Scarlett, M., del Rio, C., Reznik, D., O'Daniels, C. (1998) Oral transmission of HIV. AIDS12, 2095-2105 PMID 9833850
Sadler, M. and Nelson, M. R. (1997) Progressive multifocal leukoencephalopathy in HIV. Int. J. STD AIDS8, 351-357 PMID 9179644
Saitoh A, Hull AD, Franklin P, Spector SA. (2005) Myelomeningocele in an infant with intrauterine exposure to efavirenz. J Perinatol.25, 555-556 PMID 16047034
Satishchandra P, Nalini A, Gourie-Devi M, Khanna N, Santosh V, Ravi V, Desai A, Chandramuki A, Jayakumar PN, Shankar SK. (2000) Profile of neurologic disorders associated with HIV/AIDS from Bangalore, south India (1989-96). Indian J. Med. Res.111, 14-23 PMID
Schneider, M. F., Gange, S. J., Williams, C. M., Anastos, K., Greenblatt, R. M., Kingsley, L., Detels, R., Munoz, A. (2005) Patterns of the hazard of death after AIDS through the evolution of antiretroviral therapy: 1984-2004. AIDS19, 2009-2018 PMID 16260908
Senkaali, D., Muwonge, R., Morgan, D., Yirrell, D., Whitworth, J. and Kaleebu, P. (2005) The relationship between HIV type 1 disease progression and V3 serotype in a rural Ugandan cohort. AIDS Res. Hum. Retroviruses.20, 932-937 PMID 15585080
Sperling RS, Shapiro DE, Coombs RW, Todd JA, Herman SA, McSherry GD, O'Sullivan MJ, Van Dyke RB, Jimenez E, Rouzioux C, Flynn PM, Sullivan JL. (1996) Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. N Engl J Med.335, 1621–1629 PMID 8965861
Tang, J. and Kaslow, R. A. (2003) The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy. AIDS17, S51-S60 PMID 15080180
Tovanabutra, S., Robison, V., Wongtrakul, J., Sennum, S., Suriyanon, V., Kingkeow, D., Kawichai, S., Tanan, P., Duerr, A., Nelson, K. E. (2002) Male viral load and heterosexual transmission of HIV-1 subtype E in northern Thailand. J. Acquir. Immune. Defic. Syndr.29, 275-283 PMID 11873077
Wadia RS, Pujari SN, Kothari S, Udhar M, Kulkarni S, Bhagat S, Nanivadekar A. (2001) Neurological manifestations of HIV disease. J. Assoc. Physicians India.49, 343-348 PMID 11291974
White DA, Heaton RK, Monsch AU. (1995) Neuropsychological studies of asymptomatic human immunodeficiency virus-type-1 infected individuals. The HNRC Group. HIV Neurobehavioral Research Center. J. Int. Neuropsychol. Soc.1, 304-315 PMID 9375225
World Health Organisation (1990) Interim proposal for a WHO staging system for HIV infection and disease. WHO Wkly Epidem Rec65, 221-228 PMID 1974812
Zaidi, S. A. and Cervia, J. S. (2002) Diagnosis and management of infectious esophagitis associated with human immunodeficiency virus infection. J. Int. Assoc. Physicians AIDS Care (Chic Ill)1, 53-62 PMID 12942677
Zhu T, Korber BT, Nahmias AJ, Hooper E, Sharp PM, Ho DD.(1998) An African HIV-1 Sequence from 1959 and Implications for the Origin of the Epidemic. Nature391, 594–597 PMID 9468138
