Pericit
Pericít[1] je celica, ki s prstastimi podaljški oklepa endotelijsko cev mikrožilja (kapilar in pokapilarnih venul).[2][3] Periciti ležijo med duplikaturami bazalne lamine mikrožil[2] in komunicirajo z endotelijskimi celicami z neposrednim fizičnim stikom z njimi ter posredno s parakrinim signaliziranjem.[4] Morfologija, razporeditev, gostota in molekularne značilnosti pericitov se razlikujejo med organi in področji žilja.[5][6] Periciti imajo različne funkcije,[2] med drugim pomagajo pri vzdrževanju homeostaze in hemostaze v možganih, ki so organ z značilno obsežno prisotnostjo pericitov. V možganih periciti tudi vzdržujejo krvno-možgansko pregrado.[7] So tudi ključna sestavina živčno-žilnih (nevrovaskularnih) enot, ki zajemajo endotelijske celice, astrocite in živčne celice.[8][9] Periciti sodelujejo pri uravnavanju krvnega pretoka skozi kapilare,[10][11][12][13] in vitro pa se je tudi izkazalo, da sodelujejo pri odstranjevanju in fagocitozi celičnega drobirja.[14] Pomanjkanje pericitov v osrednjem živčevju poveča prepustnost krvno-možganske pregrade.[7]
Sklici
- ↑ Dore-Duffy, P. (2008). »Pericytes: Pluripotent cells of the blood brain barrier«. Current Pharmaceutical Design. 14 (16): 1581–93. doi:10.2174/138161208784705469. PMID 18673199.
- ↑ 2,0 2,1 2,2 https://www.termania.net/slovarji/slovenski-medicinski-slovar/5532284/pericit?query=Pericit&SearchIn=All, Slovenski medicinski e-slovar, vpogled: 6. 6. 2025.
- ↑ Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O (Januar 2015). »Pericytes at the intersection between tissue regeneration and pathology«. Clinical Science. 128 (2): 81–93. doi:10.1042/CS20140278. PMC 4200531. PMID 25236972.
- ↑ Bergers G, Song S (Oktober 2005). »The role of pericytes in blood-vessel formation and maintenance«. Neuro-Oncology. 7 (4): 452–64. doi:10.1215/S1152851705000232. PMC 1871727. PMID 16212810.
- ↑ Sims, David E. (Januar 1986). »The pericyte—A review«. Tissue and Cell (v angleščini). 18 (2): 153–174. doi:10.1016/0040-8166(86)90026-1. PMID 3085281.
- ↑ Muhl, Lars; Genové, Guillem; Leptidis, Stefanos; Liu, Jianping; He, Liqun; Mocci, Giuseppe; Sun, Ying; Gustafsson, Sonja; Buyandelger, Byambajav; Chivukula, Indira V.; Segerstolpe, Åsa (december 2020). »Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination«. Nature Communications (v angleščini). 11 (1): 3953. Bibcode:2020NatCo..11.3953M. doi:10.1038/s41467-020-17740-1. ISSN 2041-1723. PMC 7414220. PMID 32769974.
{{navedi časopis}}: Vzdrževanje CS1: samodejni prevod datuma (povezava) - ↑ 7,0 7,1 Winkler EA, Bell RD, Zlokovic BV (Oktober 2011). »Central nervous system pericytes in health and disease«. Nature Neuroscience. 14 (11): 1398–1405. doi:10.1038/nn.2946. PMC 4020628. PMID 22030551.
- ↑ Dore-Duffy P, Cleary K (2011). »Morphology and properties of pericytes«. The Blood-Brain and Other Neural Barriers. Methods in Molecular Biology. Zv. 686. str. 49–68. doi:10.1007/978-1-60761-938-3_2. ISBN 978-1-60761-937-6. PMID 21082366.
- ↑ Liebner S, Czupalla CJ, Wolburg H (2011). »Current concepts of blood-brain barrier development«. The International Journal of Developmental Biology. 55 (4–5): 467–76. doi:10.1387/ijdb.103224sl. PMID 21769778.
- ↑ Hartmann, David A.; Berthiaume, Andrée-Anne; Grant, Roger I.; Harrill, Sarah A.; Koski, Tegan; Tieu, Taryn; McDowell, Konnor P.; Faino, Anna V.; Kelly, Abigail L.; Shih, Andy Y. (Maj 2021). »Brain capillary pericytes exert a substantial but slow influence on blood flow«. Nature Neuroscience (v angleščini). 24 (5): 633–645. doi:10.1038/s41593-020-00793-2. ISSN 1097-6256. PMC 8102366. PMID 33603231.
- ↑ Hill RA, Tong L, Yuan P, Murikinati S, Gupta S, Grutzendler J (Julij 2015). »Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes«. Neuron. 87 (1): 95–110. doi:10.1016/j.neuron.2015.06.001. PMC 4487786. PMID 26119027.
- ↑ Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M, Attwell D (april 2014). »Capillary pericytes regulate cerebral blood flow in health and disease«. Nature. 508 (7494): 55–60. Bibcode:2014Natur.508...55H. doi:10.1038/nature13165. PMC 3976267. PMID 24670647.
{{navedi časopis}}: Vzdrževanje CS1: samodejni prevod datuma (povezava) - ↑ Peppiatt CM, Howarth C, Mobbs P, Attwell D (Oktober 2006). »Bidirectional control of CNS capillary diameter by pericytes«. Nature. 443 (7112): 700–4. Bibcode:2006Natur.443..700P. doi:10.1038/nature05193. PMC 1761848. PMID 17036005.
- ↑ Rustenhoven, Justin; Smyth, Leon C.; Jansson, Deidre; Schweder, Patrick; Aalderink, Miranda; Scotter, Emma L.; Mee, Edward W.; Faull, Richard L. M.; Park, Thomas I.-H.; Dragunow, Mike (december 2018). »Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction«. BMC Neuroscience (v angleščini). 19 (1): 6. doi:10.1186/s12868-018-0405-4. ISSN 1471-2202. PMC 5824614. PMID 29471788.
{{navedi časopis}}: Vzdrževanje CS1: samodejni prevod datuma (povezava)
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