BAT1

BAT1
Struktur yang tersedia
PDB	Pencarian ortolog: PDBe RCSB
Daftar kode ID PDB
	1T5I, 1T6N, 1XTI, 1XTJ, 1XTK
Pengidentifikasi
Alias	DDX39B, BAT1, D6S81E, UAP56, DEAD-box helicase 39B, DExD-box helicase 39B
ID Eksternal	OMIM: 142560; MGI: 99240; HomoloGene: 48376; GeneCards: DDX39B; OMA:DDX39B - orthologs
Nomor EC	3.6.4.13
Pola ekspresi RNA
	Ekspresi tertinggi di
	Granulosit; ; ganglionic eminence; ; Adenohipofisis; ; ventricular zone; ; right uterine tube; ; right hemisphere of cerebellum; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; left ovary; ; body of uterus;
	Ekspresi tertinggi di
	primitive streak; ; abdominal wall; ; maxillary prominence; ; mandibular prominence; ; medullary collecting duct; ; renal corpuscle; ; Vas deferens; ; efferent ductule; ; Folikel rambut; ; ventricular zone;
	Referensi data ekspresi selengkapnya
	Data ekspresi referensi lebih lanjut
Ontologi gen
Fungsi molekuler	nucleotide binding; helicase activity; protein-containing complex binding; U4 snRNA binding; ATP-dependent protein binding; Ikatan protein plasma; nucleic acid binding; hydrolase activity; ATP binding; U6 snRNA binding; ATP-dependent activity, acting on RNA; ATPase activity; pengikatan protein identik; RNA binding;
Komponen seluler	sitoplasma; transcription export complex; nuclear matrix; U6 snRNP; spliceosomal complex; U4 snRNP; Inti sel; nucleoplasm; nuclear speck; Nukleolus; protein-containing complex;
Proses biologis	mRNA splicing, via spliceosome; mRNA transport; negative regulation of DNA damage checkpoint; mRNA processing; viral mRNA export from host cell nucleus; positive regulation of translation; mRNA export from nucleus; positive regulation of DNA-templated transcription, elongation; spliceosomal complex assembly; RNA secondary structure unwinding; Penjalinan RNA; positive regulation of DNA biosynthetic process; liver development; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of vascular associated smooth muscle cell proliferation; mRNA 3'-end processing; termination of RNA polymerase II transcription; RNA export from nucleus; transpor;
	Sumber:Amigo / QuickGO
Ortologi
	7919
	53817
ENSG00000198563; ENSG00000225073; ENSG00000237889; ENSG00000229496; ENSG00000215425;
	ENSG00000235439; ENSG00000225859; ENSG00000230624
	ENSMUSG00000019432
	Q13838
	Q9Z1N5
	NM_004640; NM_080598
	NM_001252457; NM_019693
	NP_004631; NP_542165
	NP_001239386; NP_062667
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Spliceosome RNA helicase BAT1 adalah enzim yang pada manusia disandi oleh gen BAT1.^[3]^[4]^[5]

Gen ini menyandi anggota keluarga DEAD box dari ATPase yang bergantung pada RNA, yang memediasi hidrolisis ATP selama penyambungan pre-mRNA (pre-mRNA splicing). Protein yang disandi merupakan faktor penyambungan (splicing factor) esensial yang diperlukan untuk asosiasi ribonukleoprotein nuklear kecil U2 dengan pre-mRNA, dan juga memainkan peran penting dalam ekspor mRNA dari nukleus ke sitoplasma. Sekelompok gen, BAT1-BAT5, terlokalisasi di sekitar gen untuk TNF alfa dan TNF beta. Gen-gen ini semuanya berada di dalam wilayah kompleks histokompatibilitas utama kelas III manusia. Mutasi pada gen ini mungkin dikaitkan dengan artritis reumatoid. Varian transkrip yang disambung secara alternatif (alternatively spliced transcript variants) yang menyandi protein yang sama telah dijelaskan.^[5]

Referensi

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y, et al. (Aug 1995). "The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family". Genomics. 26 (2): 210–8. doi:10.1016/0888-7543(95)80203-X. PMID 7601445.
^ Spies T, Bresnahan M, Strominger JL (Dec 1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc Natl Acad Sci U S A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.
^ ^a ^b "Entrez Gene: BAT1 HLA-B associated transcript 1".

Pranala luar

Lokasi genom DDX39B manusia dan halaman rincian gen DDX39B dalam UCSC Genome Browser.
PDBe-KB menyediakan ikhtisar semua informasi struktur yang tersedia di PDB untuk Spliceosome RNA helicase DDX39B (BAT1) manusia

Bacaan lebih lanjut

Spies T, Blanck G, Bresnahan M, et al. (1989). "A new cluster of genes within the human major histocompatibility complex". Science. 243 (4888): 214–7. Bibcode:1989Sci...243..214S. doi:10.1126/science.2911734. PMID 2911734.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Fleckner J, Zhang M, Valcárcel J, Green MR (1997). "U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction". Genes Dev. 11 (14): 1864–72. doi:10.1101/gad.11.14.1864. PMID 9242493.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Allcock RJ, Price P, Gaudieri S, et al. (1999). "Characterisation of the human central MHC gene, BAT1: genomic structure and expression". Exp. Clin. Immunogenet. 16 (2): 98–106. doi:10.1159/000019100. PMID 10343160. S2CID 22003689.
Ota M, Katsuyama Y, Kimura A, et al. (2001). "A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region". Genomics. 71 (3): 263–70. doi:10.1006/geno.2000.6371. PMID 11170743.
Allcock RJ, Williams JH, Price P (2001). "The central MHC gene, BAT1, may encode a protein that down-regulates cytokine production". Genes Cells. 6 (5): 487–94. doi:10.1046/j.1365-2443.2001.00435.x. PMID 11380625. S2CID 10605522.
Luo ML, Zhou Z, Magni K, et al. (2001). "Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly". Nature. 413 (6856): 644–7. Bibcode:2001Natur.413..644L. doi:10.1038/35098106. PMID 11675789. S2CID 4395388.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Strässer K, Masuda S, Mason P, et al. (2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
McCracken S, Longman D, Johnstone IL, et al. (2004). "An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation". J. Biol. Chem. 278 (45): 44153–60. doi:10.1074/jbc.M306856200. PMID 12944400.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Price P, Wong AM, Williamson D, et al. (2004). "Polymorphisms at positions -22 and -348 in the promoter of the BAT1 gene affect transcription and the binding of nuclear factors". Hum. Mol. Genet. 13 (9): 967–74. doi:10.1093/hmg/ddh113. PMID 15028669.

Artikel bertopik enzim ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7601445-3] Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y, et al. (Aug 1995). "The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family". Genomics. 26 (2): 210–8. doi:10.1016/0888-7543(95)80203-X. PMID 7601445.

[pmid2813433-4] Spies T, Bresnahan M, Strominger JL (Dec 1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc Natl Acad Sci U S A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.

[entrez-5] "Entrez Gene: BAT1 HLA-B associated transcript 1".

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BAT1

Referensi

Pranala luar

Bacaan lebih lanjut

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