Inosina
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| Data farmakokinetika | |
| Metabolisme | Hati |
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| ECHA InfoCard | 100.000.355 |
| Data sifat kimia dan fisik | |
| Rumus | C10H12N4O5 |
| Massa molar | 268,23 g·mol−1 |
| Model 3D (JSmol) | |
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Inosina merupakan nukleosida purina yang dibentuk oleh hipoksantina terikat dengan ribosa.[1]Senyawa ini pertama kali ditemukan pada tahun 1965 oleh Robert William Holley di tRNA,[2] Inosina dapat ditemukan tRNA pada pada posisi 34, 37 dan 57 urutan basa yang merupakan hasil deaminasi yang dikatalisis oleh Adenosina deaminase di tRNA.[3]
Referensi
- ^ Srinivasan, Sundaramoorthy; Torres, Adrian Gabriel; Ribas de Pouplana, Lluís (2021-04). "Inosine in Biology and Disease". Genes (dalam bahasa Inggris). 12 (4): 600. doi:10.3390/genes12040600. ISSN 2073-4425. PMC 8072771. PMID 33921764. Pemeliharaan CS1: DOI bebas tanpa ditandai (link) Pemeliharaan CS1: Format PMC (link)
- ^ Holley, Robert W.; Apgar, Jean; Everett, George A.; Madison, James T.; Marquisee, Mark; Merrill, Susan H.; Penswick, John Robert; Zamir, Ada (1965-03-19). "Structure of a Ribonucleic Acid". Science (dalam bahasa Inggris). 147 (3664): 1462–1465. doi:10.1126/science.147.3664.1462. ISSN 0036-8075.
- ^ Torres, Adrian Gabriel; Piñeyro, David; Rodríguez-Escribà, Marta; Camacho, Noelia; Reina, Oscar; Saint-Léger, Adélaïde; Filonava, Liudmila; Batlle, Eduard; Ribas de Pouplana, Lluís (2015-04-27). "Inosine modifications in human tRNAs are incorporated at the precursor tRNA level". Nucleic Acids Research. 43 (10): 5145–5157. doi:10.1093/nar/gkv277. ISSN 1362-4962. PMC 4446420. PMID 25916855. Pemeliharaan CS1: Format PMC (link)
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Index:
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