Obat prototipe
Dalam bidang farmakologi dan farmasi, obat prototipe adalah obat individual yang mewakili kelas obat – kelompok obat yang memiliki struktur kimia, mekanisme kerja, dan cara kerja yang serupa. Prototipe adalah obat yang paling penting, dan biasanya merupakan obat pertama yang dikembangkan dalam kelas tersebut, dan digunakan sebagai referensi untuk membandingkan semua obat lainnya.[1][2]
Contoh
- Morfin: prototipe analgesik opioid[1][3]
- Propranolol: prototipe penyekat beta[4][5]
- Klorpromazin: prototipe antipsikotik fenotiazina[6][7]
- Imipramin: prototipe antidepresan trisiklik, dan merupakan turunan dari klorpromazin[6][8]
- Diazepam: prototipe benzodiazepin[2][9]
- Difenhidramin: prototipe antihistamin etanolamina[10]
- Nifedipin: prototipe penghalang saluran kalsium dihidropiridina[11]
- Klorokuin: prototipe antimalaria[12]
- Asiklovir: prototipe antivirus yang diaktifkan oleh timidina kinase virus[13]
- Aspirin: prototipe OAINS[14]
- Amfetamin: prototipe stimulan[15][16][17]
- Omeprazol: prototipe penghambat pompa proton[18][19]
Referensi
- ^ a b Brophy, Kathleen Marion; Scarlett-Ferguson, Heather; Webber, Karen S. (1 February 2010). Clinical Drug Therapy for Canadian Practice. Lippincott Williams & Wilkins. hlm. 3. ISBN 978-1-60547-517-2.
- ^ a b Bronwen Jean Bryant; Kathleen Mary Knights (2011). Pharmacology for Health Professionals. Elsevier Australia. hlm. 16. ISBN 978-0-7295-3929-6.
- ^ "Morphine". DrugBank. 16 October 2018. Diakses tanggal 16 October 2018.
- ^ "Pharmacology Glossary".
- ^ "Propranolol". DrugBank. 16 October 2018. Diakses tanggal 16 October 2018.
- ^ a b Watanabe, T.; Wada, H. (1991). Histaminergic Neurons (dalam bahasa Estonia). Taylor & Francis. hlm. 272. ISBN 978-0-8493-6425-9. Diakses tanggal 16 October 2018.
- ^ "Chlorpromazine - MeSH". NCBI. 16 October 2018. Diakses tanggal 16 October 2018.
- ^ "Imipramine - MeSH". NCBI. 16 October 2018. Diakses tanggal 16 October 2018.
- ^ Tallarida, Ronald J. (1982). "Valium (Roche)". TOP 200. New York, NY: Springer New York. hlm. 329–331. doi:10.1007/978-1-4899-6746-6_191. ISBN 978-1-4899-6748-0.
- ^ Williams, D.A.; Foye, W.O.; Lemke, T.L. (2002). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. hlm. 799. ISBN 978-0-683-30737-5. Diakses tanggal 16 October 2018.
- ^ "Nifedipine". DrugBank. 16 October 2018. Diakses tanggal 16 October 2018.
- ^ "Chloroquine - MeSH". NCBI. 16 October 2018. Diakses tanggal 16 October 2018.
- ^ "Acyclovir". DrugBank. 16 October 2018. Diakses tanggal 16 October 2018.
- ^ "Aspirin - MeSH". NCBI. 16 October 2018. Diakses tanggal 16 October 2018.
- ^ Foley, Kevin F. (2005). "Mechanism of Action and Therapeutic Uses of Psychostimulants" (PDF). American Society for Clinical Laboratory Science. 18 (2): 107. PMID 15916243. Diakses tanggal 2025-03-07.
- ^ Bronwen Jean Bryant; Kathleen Mary Knights (2011). Pharmacology for Health Professionals. Elsevier Australia. hlm. 372. ISBN 978-0-7295-3929-6.
- ^ Calipari, Erin S.; Jones, Sara R. (April 2015). "Dopamine dynamics in the basal ganglia: Implications for Parkinson's disease and psychostimulant abuse". Neuroscience & Biobehavioral Reviews. 52 (1): 194–204. doi:10.1016/j.neubiorev.2015.02.005. PMC 4403511. PMID 25684746.
- ^ Bronwen Jean Bryant; Kathleen Mary Knights (2011). Pharmacology for Health Professionals. Elsevier Australia. hlm. 594. ISBN 978-0-7295-3929-6.
- ^ Strand, Daniel S.; Kim, Daejin; Peura, David A. (2017-01-15). "25 Years of Proton Pump Inhibitors: A Comprehensive Review". Gut and Liver (dalam bahasa Inggris). 11 (1): 27–37. doi:10.5009/gnl15502. ISSN 1976-2283. PMC 5221858. PMID 27840364.
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