BMP3
Koštanomorfogenetski protein 3, znan i kao osteogenin, jest protein koji je kod ljudi kodiran genom BMP3 sa hromosoma 4.[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 472 aminokiseline, a molekulska težina 53.372 Da.[5]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAGASRLLFL | WLGCFCVSLA | QGERPKPPFP | ELRKAVPGDR | TAGGGPDSEL | ||||
| QPQDKVSEHM | LRLYDRYSTV | QAARTPGSLE | GGSQPWRPRL | LREGNTVRSF | ||||
| RAAAAETLER | KGLYIFNLTS | LTKSENILSA | TLYFCIGELG | NISLSCPVSG | ||||
| GCSHHAQRKH | IQIDLSAWTL | KFSRNQSQLL | GHLSVDMAKS | HRDIMSWLSK | ||||
| DITQLLRKAK | ENEEFLIGFN | ITSKGRQLPK | RRLPFPEPYI | LVYANDAAIS | ||||
| EPESVVSSLQ | GHRNFPTGTV | PKWDSHIRAA | LSIERRKKRS | TGVLLPLQNN | ||||
| ELPGAEYQYK | KDEVWEERKP | YKTLQAQAPE | KSKNKKKQRK | GPHRKSQTLQ | ||||
| FDEQTLKKAR | RKQWIEPRNC | ARRYLKVDFA | DIGWSEWIIS | PKSFDAYYCS | ||||
| GACQFPMPKS | LKPSNHATIQ | SIVRAVGVVP | GIPEPCCVPE | KMSSLSILFF | ||||
| DENKNVVLKV | YPNMTVESCA | CR |
Funkcija
Protein kodiran ovim genom član je natporodice transformirajući faktor rasta beta. Kao i drugi koštanomorfogenetski proteini (BMP) je poznat po svojoj sposobnosti da indukuje razvoj kostiju i hrskavice. To je disulfid-vezani homodimer. Negativno regulira gustinu kostiju. BMP3 je antagonist drugim BMP u diferencijaciji osteogenih progenitora. Jako je eksprimiran u slomljenim tkivima.
Kancer
BMP3 je hipermetiliran u mnogim slučajevima kolorektimskog karcinoma (CRC) i stoga se zajedno s drugim hipermetiliranim genima može koristiti kao biomarker za otkrivanje CRC u ranoj fazi.[6][7]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000152785 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029335 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".
- ^ Rasmussen SL, Krarup HB, Sunesen KG, Pedersen IS, Madsen PH, Thorlacius-Ussing O (juni 2016). "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review". Colorectal Disease. 18 (6): 549–61. doi:10.1111/codi.13336. PMID 26998585. S2CID 25724654.
- ^ Kormi SM, Ardehkhani S, Kerachian MA (novembar 2017). "New insights into colorectal cancer screening and early detection tests". Colorectal Cancer. 6 (2): 63–68. doi:10.2217/crc-2017-0007.
Dopunska literatura
- Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM (mart 1990). "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci". Genomics. 6 (3): 505–20. doi:10.1016/0888-7543(90)90480-I. PMID 1970330.
- Tabas JA, Zasloff M, Wasmuth JJ, Emanuel BS, Altherr MR, McPherson JD, Wozney JM, Kaplan FS (februar 1991). "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3". Genomics. 9 (2): 283–9. doi:10.1016/0888-7543(91)90254-C. PMID 2004778.
- Paralkar VM, Nandedkar AK, Pointer RH, Kleinman HK, Reddi AH (oktobar 1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". The Journal of Biological Chemistry. 265 (28): 17281–4. PMID 2211625.
- Rosen V, Wozney JM, Wang EA, Cordes P, Celeste A, McQuaid D, Kurtzberg L (1990). "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone". Connective Tissue Research. 20 (1–4): 313–9. doi:10.3109/03008208909023902. PMID 2612162.
- Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (decembar 1988). "Novel regulators of bone formation: molecular clones and activities". Science. 242 (4885): 1528–34. doi:10.1126/science.3201241. PMID 3201241.
- Faucheux C, Ulysse F, Bareille R, Reddi AH, Amédée J (decembar 1997). "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochemical and Biophysical Research Communications. 241 (3): 787–93. doi:10.1006/bbrc.1997.7792. PMID 9434787.
- Daluiski A, Engstrand T, Bahamonde ME, Gamer LW, Agius E, Stevenson SL, Cox K, Rosen V, Lyons KM (januar 2001). "Bone morphogenetic protein-3 is a negative regulator of bone density". Nature Genetics. 27 (1): 84–8. doi:10.1038/83810. PMID 11138004. S2CID 205097212.
- Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (oktobar 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology. 16 (4): 1013–9. PMID 11642720.
- Kloen P, Di Paola M, Borens O, Richmond J, Perino G, Helfet DL, Goumans MJ (septembar 2003). "BMP signaling components are expressed in human fracture callus". Bone. 33 (3): 362–71. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778.
- Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, Jiang W, Luu HH, Luo J, Szatkowski JP, Vanichakarn P, Park JY, Li Y, Haydon RC, He TC (septembar 2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Therapy. 11 (17): 1312–20. doi:10.1038/sj.gt.3302298. PMID 15269709.
- Chen AL, Fang C, Liu C, Leslie MP, Chang E, Di Cesare PE (novembar 2004). "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage". Journal of Orthopaedic Research. 22 (6): 1188–92. doi:10.1016/j.orthres.2004.02.013. PMID 15475196. S2CID 11544281.
Vanjski linkivi
- Lokacija ljudskog genoma BMP3 i stranica sa detaljima o genu BMP3 u UCSC Genome Browseru.
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Index:
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