ELF1
E74-liki faktor 1 (transkripcijski faktor ETS-domena) je protein koji je kod ljudi kodiran genom ELF1.[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 619 aminokiselina, a molekulska težina 67.498 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAAVVQQNDL | VFEFASNVME | DERQLGDPAI | FPAVIVEHVP | GADILNSYAG | ||||
| LACVEEPNDM | ITESSLDVAE | EEIIDDDDDD | ITLTVEASCH | DGDETIETIE | ||||
| AAEALLNMDS | PGPMLDEKRI | NNNIFSSPED | DMVVAPVTHV | SVTLDGIPEV | ||||
| METQQVQEKY | ADSPGASSPE | QPKRKKGRKT | KPPRPDSPAT | TPNISVKKKN | ||||
| KDGKGNTIYL | WEFLLALLQD | KATCPKYIKW | TQREKGIFKL | VDSKAVSRLW | ||||
| GKHKNKPDMN | YETMGRALRY | YYQRGILAKV | EGQRLVYQFK | EMPKDLIYIN | ||||
| DEDPSSSIES | SDPSLSSSAT | SNRNQTSRSR | VSSSPGVKGG | ATTVLKPGNS | ||||
| KAAKPKDPVE | VAQPSEVLRT | VQPTQSPYPT | QLFRTVHVVQ | PVQAVPEGEA | ||||
| ARTSTMQDET | LNSSVQSIRT | IQAPTQVPVV | VSPRNQQLHT | VTLQTVPLTT | ||||
| VIASTDPSAG | TGSQKFILQA | IPSSQPMTVL | KENVMLQSQK | AGSPPSIVLG | ||||
| PAQVQQVLTS | NVQTICNGTV | SVASSPSFSA | TAPVVTFSPR | SSQLVAHPPG | ||||
| TVITSVIKTQ | ETKTLTQEVE | KKESEDHLKE | NTEKTEQQPQ | PYVMVVSSSN | ||||
| GFTSQVAMKQ | NELLEPNSF |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Funkcija
Ovaj gen kodira faktor transkripcije specifičan za transformaciju E26. Kodirani protein primarno se eksprimira u limfoidnim ćelijamama i može djelovati i kao pojačivač i kao potiskivač za regulaciju transkripcije različitih gena. Alternativno prerađivanje rezultira u više varijanti transkripta.[5]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000120690 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036461 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: E74-like factor 1 (ets domain transcription factor)".
- ^ "UniProt, P32519". Pristupljeno 11. 9. 2017.
Dopunaka literatura
- Xiang P, Lo C, Argiropoulos B, Lai CB, Rouhi A, Imren S, Jiang X, Mager D, Humphries RK (Sep 2010). "Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1". Experimental Hematology. 38 (9): 798–8, 808.e1-2. doi:10.1016/j.exphem.2010.06.006. PMC 3887005. PMID 20600580.
- Juang YT, Solomou EE, Rellahan B, Tsokos GC (Mar 2002). "Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain". Journal of Immunology. 168 (6): 2865–71. doi:10.4049/jimmunol.168.6.2865. PMID 11884456.
- Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (maj 1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Molecular and Cellular Biology. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
- Nishiyama C, Takahashi K, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T (Dec 2000). "Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1". Bioscience, Biotechnology, and Biochemistry. 64 (12): 2601–7. doi:10.1271/bbb.64.2601. PMID 11210123.
- Thompson CB, Wang CY, Ho IC, Bohjanen PR, Petryniak B, June CH, Miesfeldt S, Zhang L, Nabel GJ, Karpinski B (Mar 1992). "cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1". Molecular and Cellular Biology. 12 (3): 1043–53. doi:10.1128/mcb.12.3.1043. PMC 369536. PMID 1545787.
- Tsokos GC, Nambiar MP, Juang YT (Apr 2003). "Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus". Annals of the New York Academy of Sciences. 987: 240–5. doi:10.1111/j.1749-6632.2003.tb06054.x. PMID 12727645.
- Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
- Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, et al. (Jan 2013). "Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians". American Journal of Human Genetics. 92 (1): 41–51. doi:10.1016/j.ajhg.2012.11.018. PMC 3542470. PMID 23273568.
- Bassuk AG, Anandappa RT, Leiden JM (maj 1997). "Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells". Journal of Virology. 71 (5): 3563–73. doi:10.1128/JVI.71.5.3563-3573.1997. PMC 191503. PMID 9094628.
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