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Adenosine reuptake inhibitor

Adenosine

An adenosine reuptake inhibitor (AdoRI) is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine by blocking the action of one or more of the equilibrative nucleoside transporters (ENTs).[1][2][3] This in turn leads to increased extracellular concentrations of adenosine and therefore an increase in adenosinergic neurotransmission.

Main article: Reuptake inhibitor

List of AdoRIs

See also

References

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  21. ^ Allen-Gipson DS, Jarrell JC, Bailey KL, Robinson JE, Kharbanda KK, Sisson JH, Wyatt TA (2009). "Ethanol Blocks Adenosine Uptake via Inhibiting the Nucleoside Transport System in Bronchial Epithelial Cells". Alcohol Clin Exp Res. 33 (5): 791–8. doi:10.1111/j.1530-0277.2009.00897.x. PMC 2940831. PMID 19298329.
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  34. ^ Noji T, Nan-ya K, Katagiri C, Mizutani M, Sano J, Nishikawa S, Karasawa A, Kusaka H (2002). "Adenosine uptake inhibition ameliorates cerulein-induced acute pancreatitis in mice". Pancreas. 25 (4): 387–392. doi:10.1097/00006676-200211000-00011. PMID 12409834. S2CID 24260175.
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  37. ^ Boissard CG, Gribkoff VK (1993). "The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro". Neuropharmacology. 32 (2): 149–155. doi:10.1016/0028-3908(93)90095-K. PMID 8383814. S2CID 10716297.
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