PAF (Q01701) and PAFB (D0EXD3) are two members of PF11402 from Penicillium chrysogenum. PAF exhibits growth-inhibitory activity against a broad range of filamentous fungi. Evidence suggests that disruption of Ca2+ signaling/homeostasis plays an important role in the mechanistic basis of PAF as a growth inhibitor.[2] PAF also elicits hyperpolarization of the plasma membrane and the activation of ion channels, followed by an increase in reactive oxygen species in the cell and the induction of an apoptosis-like phenotype [3]
PAF and PAFB are well-tolerated by mamallian and plant cells. They have proposed uses in medicine.[4]
In humans
Human epithelium produces antifungal protein S100A7, which is not a member of this protein family. Instead, S100A7 belongs in the S100 protein family.[5] The proteins kill fungi by inducing apoptosis and/or forming pores on the cell membrane.[5]
References
^ abCampos-Olivas R, Bruix M, Santoro J, Lacadena J, Martinez del Pozo A, Gavilanes JG, Rico M (March 1995). "NMR solution structure of the antifungal protein from Aspergillus giganteus: evidence for cysteine pairing isomerism". Biochemistry. 34 (9): 3009–21. doi:10.1021/bi00009a032. PMID7893713.
