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Cloroqualone

Cloroqualone
Clinical data
Pregnancy
category
  • ?
Routes of
administration		?
ATC code
  • none
Pharmacokinetic data
Bioavailability?
Metabolism?
Elimination half-life?
Excretion?
Identifiers
  • 3-(2,6-Dichlorophenyl)-2-ethyl-4-quinazolinone
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.042.761 Edit this at Wikidata
Chemical and physical data
FormulaC16H12Cl2N2O
Molar mass319.19 g·mol−1
3D model (JSmol)
  • Clc3cccc(Cl)c3N/1C(=O)c2c(\N=C\1CC)cccc2
  • InChI=1S/C16H12Cl2N2O/c1-2-14-19-13-9-4-3-6-10(13)16(21)20(14)15-11(17)7-5-8-12(15)18/h3-9H,2H2,1H3 checkY
  • Key:SONHVLIDLXLSOL-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Cloroqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other European countries. It has sedative and antitussive properties resulting from its agonist activity at the β subtype of the GABAa receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients as a cough medicine. Cloroqualone has weaker sedative properties than methaqualone and was sold for its useful cough-suppressing effects, but was withdrawn from the French market in 1994 because of concerns about its potential for abuse and overdose.[1][2][3]

See also

References

  1. ^ "Cloroqualone". PubChem. U.S. National Library of Medicine. Retrieved 2022-07-29.
  2. ^ Elks J (November 2014). The Dictionary of Drugs: Chemical Data. Springer US. p. 304. ISBN 978-1-4757-2085-3.
  3. ^ Martindale W, Reynolds JE (1993). Martindale: The Extra Pharmacopoeia (30th ed.). London: The Pharmaceutical Press. p. 745. ISBN 978-0-85369-300-0.


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