DNA ligase (NAD+)

DNA ligase (NAD⁺) (EC 6.5.1.2, polydeoxyribonucleotide synthase (NAD⁺), polynucleotide ligase (NAD⁺), DNA repair enzyme, DNA joinase, polynucleotide synthetase (nicotinamide adenine dinucleotide), deoxyribonucleic-joining enzyme, deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic acid ligase, polynucleotide synthetase, deoxyribonucleic acid joinase, DNA-joining enzyme, polynucleotide ligase (nicotinamide adenine dinucleotide)) is an enzyme with systematic name poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming).^[1] This enzyme catalyses the following chemical reaction

NAD⁺ + (deoxyribonucleotide)_n + (deoxyribonucleotide)_m ${\displaystyle \rightleftharpoons }$ AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)_n+m

Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA.

• DNA ligase

• DNA+ligase+(NAD+) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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