Valdes-Scantling was selected by the Green Bay Packers with the 174th overall pick in the fifth round of the 2018 NFL draft.[9] He signed his rookie contract on May 7, 2018.[10] He made his NFL debut in the Packers' season opener against the Chicago Bears on September 9, 2018, recording a 21-yard kick return in the 24–23 victory.[11] He recorded his first professional reception in the following game against the Minnesota Vikings.[12] He started his first career game in place of the injured Randall Cobb in a Week 4 win over the Buffalo Bills, catching one pass for 38 yards.[13] Still starting in place of Cobb during a Week 5 loss to the Detroit Lions, Valdes-Scantling had a breakout performance, notching seven receptions for 68 yards and a touchdown.[14] He followed that up with a three-catch, 103-yard performance during a Week 6 win over the San Francisco 49ers.[15] On October 28, 2018, in a 27–29 loss to the Los Angeles Rams, he had two receptions for 45 yards, including a 40-yard receiving touchdown.[16] The following week, a 17–31 loss to the New England Patriots, he had three receptions for 101 yards.[17] Overall, he finished his rookie season with 38 receptions for 581 receiving yards and two receiving touchdowns. He finished seventh among rookies in receiving yards.[18][19]
2019
In Week 3 against the Denver Broncos, Valdes-Scantling caught six passes for 99 yards and his first receiving touchdown of the season as the Packers won 27–16.[20] During Week 7 against the Oakland Raiders, Valdes-Scantling finished with two catches for 133 receiving yards, including a 74-yard touchdown as the Packers won 42–24.[21] Overall, Valdes-Scantling finished the 2019 season with 26 receptions for 452 receiving yards and two receiving touchdowns.[22]
2020
In Week 1 against the Vikings, Valdes-Scantling caught four passes for 96 yards and his first touchdown of the season during the 43–34 win.[23] In Week 9 against the 49ers on Thursday Night Football, he had two receptions for 53 receiving yards and two touchdowns in the 34–17 victory.[24] In Week 10, against the Jacksonville Jaguars, he had four receptions for 149 receiving yards, including a 78-yard receiving touchdown, during the 24–20 win.[25] In Week 11 against the Indianapolis Colts, Valdes-Scantling recorded a key 47-yard catch on a late fourth quarter drive that resulted in a game-tying field goal by Mason Crosby.[26] However, he also lost a fumble on the Packers' second play in overtime, allowing the Colts to kick the game-winning field goal.[27]
Valdes-Scantling later tweeted that he received death threats after the game.[28][29]
Valdes-Scantling was placed on injured reserve on October 2, 2021.[31] He was activated from injured reserve on November 6, 2021.[32] In Week 11, against the Vikings, he had four receptions for 123 yards and a touchdown in the 34–31 loss.[33] He finished the 2021 season with 26 receptions for 430 receiving yards and three receiving touchdowns.[34]
Kansas City Chiefs
On March 24, 2022, Valdes-Scantling signed a three-year, $30 million contract with the Kansas City Chiefs.[35] In Week 7, against the 49ers, he had three receptions for 111 yards in the 44–23 victory.[36] In the 2022 regular season, he had 42 receptions for 687 receiving yards and two receiving touchdowns in 17 games, of which he started 11.[37] In the AFC Championship Game, Valdes-Scantling caught six passes for 116 yards and a touchdown helping the Chiefs defeat the Cincinnati Bengals 23–20.[38] Valdes-Scantling won his first Super Bowl championship in the 38–35 victory over the Philadelphia Eagles in Super Bowl LVII. He was targeted once with no receptions in the game.[39]
Valdes-Scantling caught a career-low 21 passes for 315 yards and just one touchdown in the 2023 regular season.[40] In the AFC Championship Game against the Baltimore Ravens, Valdes-Scantling caught a 32-yard pass on third down right before the two-minute warning, allowing the Chiefs to run out the rest of the clock and beat the Ravens 17–10.[41] In Super Bowl LVIII, Valdes-Scantling had three receptions for 20 yards and a touchdown in the Chiefs 25–22 victory over the San Francisco 49ers.[42] On February 28, 2024, he was released.[43]
Buffalo Bills
On May 14, 2024, Valdes-Scantling signed a one-year contract with the Buffalo Bills.[44] On October 15, 2024, following the Bills' acquisition of wide receiver Amari Cooper in a trade with the Cleveland Browns, Valdes-Scantling was released. While with the Bills, Valdes-Scantling caught two passes for 26 yards on nine targets.[45]