The format of Perversions of Science is similar to Tales from the Crypt; the latter is hosted by the Cryptkeeper, a wisecracking corpse performed by puppeteers, while Perversion of Science is hosted by a computer-generatedfemale robot named Chrome (voiced by Maureen Teefy).[3] Individual episodes begin with an introduction by Chrome, followed by a main narrative. After the narrative is complete, Chrome concludes the episode by making a comment about the story in question.[1] Unlike the Cryptkeeper, who frequently makes puns revolving around death and macabre subjects, Chrome engages more in sexual innuendo.[2]
The show featured a mix of established talent and young up-and-comers. For instance, "Panic" starred a young Jason Lee and Jamie Kennedy opposite Harvey Korman.[2]
A 40-year-old divorced but childless professor (Keith Carradine) cannot wake from his dreams. Each time he wakes up, he finds himself in another dream.
A space pilot (Kevin Pollak) has spent years in an eroding fighter with a female android (Heather Elizabeth Parkhurst). He has kept his promise to be faithful to his fiancée named Dulcine (Melanie Shatner) who is also the daughter of an Admiral (William Shatner). When he finally gets to see her, he notices that the Admiral has fitted her with an electronic chastity belt.
A scientist (Jeffrey Combs) who kills people in his impurity-purging experiments is arrested and tried. When rehabilitation fails at the hands of the prison psychiatrist (David Warner), he is sentenced to be "exiled."
A woman (Yancy Butler) re-shapes her body to perfection. She then participates in an experiment where she is sent ten years into the past where she meets a man (William McNamara) obsessed with perfection.
A grieving widower (George Newbern) volunteers to be the subject of an experiment by an ex-NASA scientist (Vincent Schiavelli) where he will be sent to another plane of existence where his murdered wife (Elizabeth Berkley) may still be alive.
In the 1930s, Bob (Jason Lee) and John (Jamie Kennedy) are among a number of people at a Halloween costume party trying to deal with the panic caused by a fictionalized version of the Orson Welles Mercury Theatre production of The War of the Worlds as people start turning up dead.
A spaceship captain (Jennifer Hetrick) and her mixed gender crew (Wil Wheaton, Sean Astin and Kathleen Wilhoite) struggle with anxiety when an unidentified extraterrestrial virus puts the ship in lockdown and activates the self-destruct sequence.
In the near future, a suburban family (Patrick Cassidy and Maxine Bahns) gets caught between groups of warring robots. When one of their robots is damaged every night, a robot repairman suggests that they buy a new one: a red, white, and blue patriot.