Perforin
Perforini so citolitični proteini, ki se nahajajo v sekretornih zrncih naravnih celic ubijalk in citotoksičnih limfocitov T. Po sprostitvi v večini primerov MACPF domena proteina napade celično membrano (plazmalemo) tuje celice in tako omogoči vgradnjo proteina v plazmalemo.[1] Čeprav so pore zadostne za uničenje (lizo) celic pri visokih koncentracijah perforinov, v normalnih pogojih pore pravzaprav omogočijo prehod grancimov, serinskih proteaz, ki v tujih celicah inducirajo apoptozo, tj. programirano celično smrt, in jo tako uničijo.[2]
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Opombe in sklici
- ↑ Tschopp J., Masson D. in Stanley K.K. (1986). »Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis«. Nature. 322 (6082): 831–4. doi:10.1038/322831a0. PMID 2427956.
- ↑ Rosado, C.J. s sod. (2007). »A common fold mediates vertebrate defense and bacterial attack«. Science. 317 (5844): 1548–51. doi:10.1126/science.1144706. PMID 17717151.
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