CXCL2
| Hemokinski ligand 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||
| Simbol | CXCL2 | ||||||
| Alt. simboli | SCYB2, GRO2, GROb, MIP-2a, MGSA-b, CINC-2a | ||||||
| NCBI gen | 2920 | ||||||
| HGNC | 4603 | ||||||
| OMIM | 139110 | ||||||
| RefSeq | NM_002089 | ||||||
| UniProt | P19875 | ||||||
| Ostali podaci | |||||||
| Lokus | Hrom. 4 q21 | ||||||
| |||||||
Hemokinski ligand 2 (X-C motiv) jest mali citokin koji je kod ljudi kodiran genom CXCL2 sa hromosoma 4. Pripada porodici CXC hemokina koja se također naziva makrofagni inflamatorni protein 2-alfa (MIP2-alfa), protein beta reguliran rastom (Gro-beta) i Gro onkogen- 2 (Gro-2). CXCL2 je 90% identičan u sekvenci aminokiselina kao srodni hemokin, CXCL1.
Ovaj hemokin luče monociti i makrofagi i ima hemotaksije za polimorfojedarne leukocite i hematopoetske matične ćelijee.[5][6][7] Na hromosomu 4, gen za CXCL2 nalazi se u grupi drugih CXC hemokina.[8] CXCL2 mobilizira ćelije, interakcijom sa ćelijskom površinom preko hemokinskog receptora koja se naziva hemokinski receptori (CXCR1 i CXCR2.[7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 107 aminokiselina, а molekulska težina 11.389 Da.[9]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MARATLSAAP | SNPRLLRVAL | LLLLLVAASR | RAAGAPLATE | LRCQCLQTLQ | ||||
| GIHLKNIQSV | KVKSPGPHCA | QTEVIATLKN | GQKACLNPAS | PMVKKIIEKM | ||||
| LKNGKSN |
Funkcija
CXCL2, kao i srodni hemokini, također je moćan hemoatraktant neutrofila i uključen je u mnoge imunske odgovore, uključujući zacjeljivanje rana, metastaze raka i angiogenezu.[10] Studija je objavljena 2013. testirajući ulogu CXCL2, CXCL3 i CXCL1 u migraciji glatkih mišićnih ćelija disajnih puteva (ASMC), što ima značajnu ulogu u astmi. Rezultati ove studije pokazali su da i CXCL2 i CXCL3 pomažu u posredovanju migracije normalnnih i astmarskih ASMC-a kroz različite mehanizme.[10]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000081041 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029380 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A (januar 1989). "Identification and characterization of macrophage inflammatory protein 2". Proceedings of the National Academy of Sciences of the United States of America. 86 (2): 612–6. Bibcode:1989PNAS...86..612W. doi:10.1073/pnas.86.2.612. PMC 286522. PMID 2643119.
- ^ Iida N, Grotendorst GR (oktobar 1990). "Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue". Molecular and Cellular Biology. 10 (10): 5596–9. doi:10.1128/mcb.10.10.5596. PMC 361282. PMID 2078213.
- ^ a b Pelus LM, Fukuda S (august 2006). "Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties". Experimental Hematology. 34 (8): 1010–20. doi:10.1016/j.exphem.2006.04.004. PMID 16863907.
- ^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and Cell Genetics. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.
- ^ "UniProt, P19875" (jezik: engleski). Pristupljeno 23. 10. 2021.
- ^ a b Al-Alwan LA, Chang Y, Mogas A, Halayko AJ, Baglole CJ, Martin JG, Rousseau S, Eidelman DH, Hamid Q (septembar 2013). "Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration". Journal of Immunology. 191 (5): 2731–41. doi:10.4049/jimmunol.1203421. PMC 3748335. PMID 23904157.
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