Small nucleolar RNA SNORD21

Small nucleolar RNA SNORD21
Small nucleolar RNA SNORD21
	Predicted secondary structure and sequence conservation of SNORD21
Identifiers
Symbol	SNORD21
Alt. Symbols	U21
Rfam	RF00068
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe

In molecular biology, U21 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. U21 is encoded within an intron of the gene for ribosomal protein L5 in mammals,^[1] but within introns of the ADP ribosylation factor gene in Drosophila.^[2] U21 snoRNA has a 13 nucleotide region of complementarity with an invariant region of eukaryotic 28S ribosomal RNA.

References

^ Qu LH, Nicoloso M, Michot B, Azum MC, Caizergues-Ferrer M, Renalier MH, Bachellerie JP (October 1994). "U21, a novel small nucleolar RNA with a 13 nt. complementarity to 28S rRNA, is encoded in an intron of ribosomal protein L5 gene in chicken and mammals". Nucleic Acids Research. 22 (20): 4073–81. doi:10.1093/nar/22.20.4073. PMC 331892. PMID 7937132.
^ Renalier MH, Nicoloso M, Qu LH, Bachellerie JP (February 1996). "SnoRNA U21 is also intron-encoded in Drosophila melanogaster but in a different host-gene as compared to warm-blooded vertebrates". FEBS Letters. 379 (3): 212–6. doi:10.1016/0014-5793(95)01511-6. PMID 8603691. S2CID 28632486.

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