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Small nucleolar RNA SNORD24

Small nucleolar RNA SNORD24
Predicted secondary structure and sequence conservation of SNORD24
Identifiers
SymbolSNORD24
Alt. SymbolsU24
RfamRF00069
Other data
RNA typeGene; snRNA; snoRNA; C/D-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

In molecular biology, U24 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs.[1] C/D box snoRNAs have been shown to act as methylation guides for a number of RNA targets.[2][3] U24 is encoded within an intron of the gene for ribosomal protein L7a in mammals, chicken and Fugu.[4] The U76/SNORD76 snoRNA is found in an intron of the uRNA host gene (UHG) growth arrest specific 5 (GAS5) transcript gene.[5] snoRNAs Z20 and U76 snoRNAs show clear similarity to U24.

An experiment that looked at 22 different non-small-cell lung cancer tissues found that SNORD33, SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues.[6]

References

  1. ^ Qu LH, Henry Y, Nicoloso M, Michot B, Azum MC, Renalier MH, Caizergues-Ferrer M, Bachellerie JP (July 1995). "U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementarities to 28S rRNA". Nucleic Acids Research. 23 (14): 2669–76. doi:10.1093/nar/23.14.2669. PMC 307091. PMID 7651828.
  2. ^ Nicoloso M, Qu LH, Michot B, Bachellerie JP (July 1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". Journal of Molecular Biology. 260 (2): 178–95. doi:10.1006/jmbi.1996.0391. PMID 8764399.
  3. ^ Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (June 1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–88. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114. S2CID 10418885.
  4. ^ Gilley J, Fried M (July 1998). "Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants". DNA and Cell Biology. 17 (7): 591–602. doi:10.1089/dna.1998.17.591. PMID 9703018.
  5. ^ Hirose T, Steitz JA (November 2001). "Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 98 (23): 12914–9. Bibcode:2001PNAS...9812914H. doi:10.1073/pnas.231490998. JSTOR 3057015. PMC 60799. PMID 11606788.
  6. ^ Liao J, Yu L, Mei Y, Guarnera M, Shen J, Li R, Liu Z, Jiang F (July 2010). "Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer". Molecular Cancer. 9: 198. doi:10.1186/1476-4598-9-198. PMC 2919450. PMID 20663213.


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