Alfa-2-adrenergički receptori su 3 visoko homologna podtipa: alfa2A, alfa2B, i alfa2C. Ti receptori imaju kritičnu ulogu u regulaciji otpuštanja neurotransmitera iz simpatičkih nerva i iz adrenergičkih neurona centralnog nervnog sistema. Ispitivanja na miševima su pokazala da su oba, alfa2A i alfa2C, podtipa neophodna za normalnu presinaptičku kontrolu otpuštanja transmitera iz simpatičkih nerva u srcu i iz centralnih noradrenergičkih neurona. Alfa2A podtip inhibira otpuštanje transmitera na visokim stimulacionim frekvencijama, dok alfa2C podtip modulira neurotransmisiju na niskim nivoima nervne aktivnosti.
Gen
Ovaj gen kodira alfa2A tip receptora. On ne sadrži introne.[1]
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„α2A-adrenoceptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 02. 04. 2015. г.
