Protein kodiran ovim genom pripada familiji G-protein spregnutih receptora, koji su preferentno aktivirani nukleotidimaadenozina i uridina. Ovaj receptor je responzivan na UDP, parcijalno responzivan na UTP i ADP, i ne aktivira ga ATP. Poznate su četiri transkriptne varijante koje kodiraju istu izoformu gena.[2]
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Maier R, Glatz A, Mosbacher J, Bilbe G (1997). „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun. 240 (2): 298—302. PMID9412455.
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Brinson AE, Harden TK (2001). „Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.”. J. Biol. Chem. 276 (15): 11939—48. PMID11114308. doi:10.1074/jbc.M009909200.
Moore DJ; Chambers JK; Wahlin JP; et al. (2001). „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta. 1521 (1-3): 107—19. PMID11690642.CS1 одржавање: Експлицитна употреба et al. (веза)
Hou M; Harden TK; Kuhn CM; et al. (2002). „UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.”. Am. J. Physiol. Heart Circ. Physiol. 282 (2): H784—92. PMID11788430. doi:10.1152/ajpheart.00997.2000.CS1 одржавање: Експлицитна употреба et al. (веза)
Loomis WH; Namiki S; Ostrom RS; et al. (2003). „Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation.”. J. Biol. Chem. 278 (7): 4590—6. PMID12464620. doi:10.1074/jbc.M207868200.CS1 одржавање: Експлицитна употреба et al. (веза)
Kim SG; Soltysiak KA; Gao ZG; et al. (2003). „Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.”. Biochem. Pharmacol. 65 (6): 923—31. PMID12623123. doi:10.1016/S0006-2952(02)01614-3.CS1 одржавање: Експлицитна употреба et al. (веза)
Schafer R, Sedehizade F, Welte T, Reiser G (2003). „ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells.”. Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2): L376—85. PMID12691958. doi:10.1152/ajplung.00447.2002.
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Cox MA; Gomes B; Palmer K; et al. (2005). „The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP.”. Biochem. Biophys. Res. Commun. 330 (2): 467—73. PMID15796906. doi:10.1016/j.bbrc.2005.03.004.CS1 одржавање: Експлицитна употреба et al. (веза)
Khine AA; Del Sorbo L; Vaschetto R; et al. (2006). „Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway.”. Blood. 107 (7): 2936—42. PMID16322472. doi:10.1182/blood-2005-06-2314.CS1 одржавање: Експлицитна употреба et al. (веза)
Wihlborg AK; Balogh J; Wang L; et al. (2006). „Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction.”. Circ. Res. 98 (7): 970—6. PMID16543499. doi:10.1161/01.RES.0000217402.73402.cd.CS1 одржавање: Експлицитна употреба et al. (веза)
Dulong S, Bernard K, Ehrenfeld J (2007). „Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells.”. Cell. Physiol. Biochem. 20 (5): 483—94. PMID17762175. doi:10.1159/000107532.
Spoljašnje veze
„P2Y Receptors: P2Y6”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 17. 02. 2015. г.
